Nar H - Search Results

1

Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.

Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L. Niu Y, et al. Among authors: nar h. Nature. 2022 Jan;601(7892):280-284. doi: 10.1038/s41586-021-04212-9. Epub 2021 Dec 8. Nature. 2022. PMID: 34880493

2

Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.

Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H. Hoerer S, et al. Among authors: nar h. J Mol Biol. 2003 Dec 12;334(5):853-61. doi: 10.1016/j.jmb.2003.10.033. J Mol Biol. 2003. PMID: 14643652

3

Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.

Ebenhoch R, Akhdar A, Reboll MR, Korf-Klingebiel M, Gupta P, Armstrong J, Huang Y, Frego L, Rybina I, Miglietta J, Pekcec A, Wollert KC, Nar H. Ebenhoch R, et al. Among authors: nar h. Nat Commun. 2019 Nov 26;10(1):5379. doi: 10.1038/s41467-019-13343-7. Nat Commun. 2019. PMID: 31772377 Free PMC article.

4

Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.

Ebenhoch R, Bauer M, Romig H, Gottschling D, Kley JT, Heine N, Weber A, Uphues I, Nar H, Pautsch A. Ebenhoch R, et al. Among authors: nar h. Acta Crystallogr D Struct Biol. 2023 Oct 1;79(Pt 10):871-880. doi: 10.1107/S2059798323006137. Epub 2023 Sep 15. Acta Crystallogr D Struct Biol. 2023. PMID: 37712434

5

Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.

Nar H, Bauer M, Schmid A, Stassen JM, Wienen W, Priepke HW, Kauffmann IK, Ries UJ, Hauel NH. Nar H, et al. Structure. 2001 Jan 10;9(1):29-37. doi: 10.1016/s0969-2126(00)00551-7. Structure. 2001. PMID: 11342132 Free article.

6

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.

Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, Reinert D, Bauer M, Weixler L, Zeeb M, Vonck J, Nar H. Ebenhoch R, et al. Among authors: nar h. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31838-31849. doi: 10.1073/pnas.2013473117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229582 Free PMC article.

7

Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.

Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, Hinz I, Feiler M, Müller K, Nar H. Ebenhoch R, et al. Among authors: nar h. J Struct Biol. 2021 Mar;213(1):107691. doi: 10.1016/j.jsb.2020.107691. Epub 2020 Dec 31. J Struct Biol. 2021. PMID: 33387654 Free article.

8

A specific antidote for dabigatran: functional and structural characterization.

Schiele F, van Ryn J, Canada K, Newsome C, Sepulveda E, Park J, Nar H, Litzenburger T. Schiele F, et al. Among authors: nar h. Blood. 2013 May 2;121(18):3554-62. doi: 10.1182/blood-2012-11-468207. Epub 2013 Mar 8. Blood. 2013. PMID: 23476049 Free article.

9

Biophysics in drug discovery: impact, challenges and opportunities.

Renaud JP, Chung CW, Danielson UH, Egner U, Hennig M, Hubbard RE, Nar H. Renaud JP, et al. Among authors: nar h. Nat Rev Drug Discov. 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12. Nat Rev Drug Discov. 2016. PMID: 27516170 Free article. Review.

10

Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.

Rübbelke M, Hamilton J, Binder F, Bauer M, King J, Nar H, Zeeb M. Rübbelke M, et al. Among authors: nar h. J Med Chem. 2021 Nov 11;64(21):15629-15638. doi: 10.1021/acs.jmedchem.1c00686. Epub 2021 Oct 21. J Med Chem. 2021. PMID: 34672548 Free article.

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