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A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.
Rodríguez-Barrueco R, Latorre J, Devis-Jáuregui L, Lluch A, Bonifaci N, Llobet FJ, Olivan M, Coll-Iglesias L, Gassner K, Davis ML, Moreno-Navarrete JM, Castells-Nobau A, Plata-Peña L, Dalmau-Pastor M, Höring M, Liebisch G, Olkkonen VM, Arnoriaga-Rodríguez M, Ricart W, Fernández-Real JM, Silva JM, Ortega FJ, Llobet-Navas D. Rodríguez-Barrueco R, et al. Among authors: olkkonen vm. Adv Sci (Weinh). 2022 Feb;9(4):e2104759. doi: 10.1002/advs.202104759. Epub 2021 Dec 13. Adv Sci (Weinh). 2022. PMID: 34898027 Free PMC article.
MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes.
Mysore R, Ortega FJ, Latorre J, Ahonen M, Savolainen-Peltonen H, Fischer-Posovszky P, Wabitsch M, Olkkonen VM, Fernández-Real JM, Haridas PAN. Mysore R, et al. Among authors: olkkonen vm. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4001-4012. doi: 10.1210/jc.2017-00453. J Clin Endocrinol Metab. 2017. PMID: 28938482
Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes.
Latorre J, Ortega FJ, Liñares-Pose L, Moreno-Navarrete JM, Lluch A, Comas F, Oliveras-Cañellas N, Ricart W, Höring M, Zhou Y, Liebisch G, Nidhina Haridas PA, Olkkonen VM, López M, Fernández-Real JM. Latorre J, et al. Among authors: olkkonen vm. EBioMedicine. 2020 Mar;53:102697. doi: 10.1016/j.ebiom.2020.102697. Epub 2020 Mar 3. EBioMedicine. 2020. PMID: 32143184 Free PMC article.
Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.
Ahonen MA, Asghar MY, Parviainen SJ, Liebisch G, Höring M, Leidenius M, Fischer-Posovszky P, Wabitsch M, Mikkola TS, Törnquist K, Savolainen-Peltonen H, Haridas PAN, Olkkonen VM. Ahonen MA, et al. Among authors: olkkonen vm. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158841. doi: 10.1016/j.bbalip.2020.158841. Epub 2020 Oct 16. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33075494
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis.
Lluch A, Veiga SR, Latorre J, Moreno-Navarrete JM, Bonifaci N, Dien Nguyen V, Zhou Y, Höring M, Liebisch G, Olkkonen VM, Llobet-Navas D, Thomas G, Rodríguez-Barrueco R, Fernández-Real JM, Kozma SC, Ortega FJ. Lluch A, et al. Among authors: olkkonen vm. JCI Insight. 2022 Jul 22;7(14):e150461. doi: 10.1172/jci.insight.150461. JCI Insight. 2022. PMID: 35737463 Free PMC article.
MicroRNA-192* impairs adipocyte triglyceride storage.
Mysore R, Zhou Y, Sädevirta S, Savolainen-Peltonen H, Nidhina Haridas PA, Soronen J, Leivonen M, Sarin AP, Fischer-Posovszky P, Wabitsch M, Yki-Järvinen H, Olkkonen VM. Mysore R, et al. Among authors: olkkonen vm. Biochim Biophys Acta. 2016 Apr;1861(4):342-51. doi: 10.1016/j.bbalip.2015.12.019. Epub 2015 Dec 30. Biochim Biophys Acta. 2016. PMID: 26747651
221 results