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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mamais A, et al. Among authors: pellegrini l. PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec. PLoS Biol. 2021. PMID: 34914695 Free PMC article.
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Beilina A, Bonet-Ponce L, Kumaran R, Kordich JJ, Ishida M, Mamais A, Kaganovich A, Saez-Atienzar S, Gershlick DC, Roosen DA, Pellegrini L, Malkov V, Fell MJ, Harvey K, Bonifacino JS, Moore DJ, Cookson MR. Beilina A, et al. Among authors: pellegrini l. Cell Rep. 2020 May 5;31(5):107614. doi: 10.1016/j.celrep.2020.107614. Cell Rep. 2020. PMID: 32375042 Free PMC article.
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Heaton GR, Landeck N, Mamais A, Nalls MA, Nixon-Abell J, Kumaran R, Beilina A, Pellegrini L, Li Y; International Parkinson Disease Genomics Consortium (IPDGC); Harvey K, Cookson MR. Heaton GR, et al. Among authors: pellegrini l. Neurobiol Dis. 2020 Jul;141:104948. doi: 10.1016/j.nbd.2020.104948. Epub 2020 May 17. Neurobiol Dis. 2020. PMID: 32434048 Free PMC article.
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Harvey K, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mamais A, et al. Among authors: pellegrini l. PLoS Biol. 2022 May 4;20(5):e3001621. doi: 10.1371/journal.pbio.3001621. eCollection 2022 May. PLoS Biol. 2022. PMID: 35507910 Free PMC article.
Back to the tubule: microtubule dynamics in Parkinson's disease.
Pellegrini L, Wetzel A, Grannó S, Heaton G, Harvey K. Pellegrini L, et al. Cell Mol Life Sci. 2017 Feb;74(3):409-434. doi: 10.1007/s00018-016-2351-6. Epub 2016 Sep 6. Cell Mol Life Sci. 2017. PMID: 27600680 Free PMC article. Review.
427 results