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Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA.
Shebanova R, Nikitchina N, Shebanov N, Mekler V, Kuznedelov K, Ulashchik E, Vasilev R, Sharko O, Shmanai V, Tarassov I, Severinov K, Entelis N, Mazunin I. Shebanova R, et al. Among authors: mekler v. Nucleic Acids Res. 2022 Jan 25;50(2):1162-1173. doi: 10.1093/nar/gkab1227. Nucleic Acids Res. 2022. PMID: 34951459 Free PMC article.
Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation.
Kuznedelov K, Mekler V, Lemak S, Tokmina-Lukaszewska M, Datsenko KA, Jain I, Savitskaya E, Mallon J, Shmakov S, Bothner B, Bailey S, Yakunin AF, Severinov K, Semenova E. Kuznedelov K, et al. Among authors: mekler v. Nucleic Acids Res. 2016 Dec 15;44(22):10849-10861. doi: 10.1093/nar/gkw914. Epub 2016 Oct 13. Nucleic Acids Res. 2016. PMID: 27738137 Free PMC article.
Defining the seed sequence of the Cas12b CRISPR-Cas effector complex.
Jain I, Minakhin L, Mekler V, Sitnik V, Rubanova N, Severinov K, Semenova E. Jain I, et al. Among authors: mekler v. RNA Biol. 2019 Apr;16(4):413-422. doi: 10.1080/15476286.2018.1495492. Epub 2018 Aug 17. RNA Biol. 2019. PMID: 30022698 Free PMC article.
40 results