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90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats.
Hu SC, Min S, Kang HK, Yang DJ, Basavarajappa M, Lewis SM, Davis KJ, Patton RE, Bryant MS, Sepehr E, Trbojevich R, Pearce MG, Bishop ME, Ding W, Heflich RH, Maisha MP, Felton R, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: tang y. Food Chem Toxicol. 2022 Feb;160:112780. doi: 10.1016/j.fct.2021.112780. Epub 2021 Dec 26. Food Chem Toxicol. 2022. PMID: 34965465
Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays.
Mittelstaedt RA, Dobrovolsky VN, Revollo JR, Pearce MG, Wang Y, Dad A, McKinzie PB, Rosenfeldt H, Yucesoy B, Yeager R, Hu SC, Tang Y, Min S, Kang HK, Yang DJ, Basavarajappa M, Heflich RH. Mittelstaedt RA, et al. Among authors: tang y. Mutat Res Genet Toxicol Environ Mutagen. 2019 Jan;837:65-72. doi: 10.1016/j.mrgentox.2018.10.007. Epub 2018 Oct 29. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 30595212
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage.
Hu SC, Bryant MS, Sepehr E, Kang HK, Trbojevich R, Lagaud G, Mehta D, Ding W, Mittelstaedt RA, Pearce MG, Bishop ME, Davis KJ, Lewis SM, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: tang y. Toxicol Sci. 2021 Jul 16;182(1):10-28. doi: 10.1093/toxsci/kfab049. Toxicol Sci. 2021. PMID: 33944952
14-Day Nose-Only Inhalation Toxicity and Haber's Rule Study of NNK in Sprague-Dawley Rats.
Hu SC, Min S, Kang HK, Yang DJ, Lewis SM, Davis KJ, Patton RE, Bryant MS, Sepehr E, Trbojevich R, Pearce MG, Bishop ME, Heflich RH, Maisha MP, Felton R, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: tang y. Toxicol Sci. 2021 Sep 28;183(2):319-337. doi: 10.1093/toxsci/kfab094. Toxicol Sci. 2021. PMID: 34329464
Pharmacokinetic Analysis of Nicotine and Its Metabolites (Cotinine and trans-3'-Hydroxycotinine) in Male Sprague-Dawley Rats Following Nose-Only Inhalation, Oral Gavage, and Intravenous Infusion of Nicotine.
Tang Y, Bryant MS, Li M, Min S, Pellar G, Wu Q, Yang DJ, Kang HK, Sepehr E, He X, McLellen F, Lewis SM, Greenhaw J, Fisher J, Yang X, Chemerynski S, Yee SB, Rosenfeldt H, Yeager RP, Howard PC, Hu SC, Roqué P, Goel R, Kc P, Yi J. Tang Y, et al. Toxicol Sci. 2024 Sep 12:kfae120. doi: 10.1093/toxsci/kfae120. Online ahead of print. Toxicol Sci. 2024. PMID: 39270062
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