Giorgi G - Search Results

1

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.

Martín-Cámara O, Arribas M, Wells G, Morales-Tenorio M, Martín-Requero Á, Porras G, Martínez A, Giorgi G, López-Alvarado P, Lastres-Becker I, Menéndez JC. Martín-Cámara O, et al. Among authors: giorgi g. J Med Chem. 2022 Feb 10;65(3):1867-1882. doi: 10.1021/acs.jmedchem.1c01255. Epub 2022 Jan 5. J Med Chem. 2022. PMID: 34985276 Free PMC article.

2

Synthesis of benzo- and naphtho-fused bicyclo[n.3.1]alkane frameworks with a bridgehead nitrogen function by palladium-catalyzed intramolecular α'-arylation of α-nitroketones.

Giorgi G, Maiti S, López-Alvarado P, Menéndez JC. Giorgi G, et al. Org Biomol Chem. 2011 Apr 21;9(8):2722-30. doi: 10.1039/c0ob00526f. Epub 2011 Feb 25. Org Biomol Chem. 2011. PMID: 21359298

3

A one-pot sequence for the efficient synthesis of highly functionalized macrocarbocycles or bridged 2,8-dioxabicyclo[3.2.1]octanes from 1-nitrobicyclic compounds.

Giorgi G, López-Alvarado P, Menéndez JC. Giorgi G, et al. Org Biomol Chem. 2012 Jul 14;10(26):5131-6. doi: 10.1039/c2ob25274k. Epub 2012 May 28. Org Biomol Chem. 2012. PMID: 22641240

4

A systematic ¹ H- and ¹³ C-NMR spectral analysis of bicyclo[n.3.1]alkanone systems: Determination of the relative configuration of the stereogenic centres and conformation of the six-membered ring.

Giorgi G, López-Alvarado P, Menéndez JC. Giorgi G, et al. Magn Reson Chem. 2017 Nov;55(11):1044-1051. doi: 10.1002/mrc.4627. Epub 2017 Jul 10. Magn Reson Chem. 2017. PMID: 28644528 No abstract available.

5

Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes.

Ruiz M, López-Alvarado P, Giorgi G, Menéndez JC. Ruiz M, et al. Among authors: giorgi g. Chem Soc Rev. 2011 Jul;40(7):3445-54. doi: 10.1039/c1cs15018a. Epub 2011 Apr 11. Chem Soc Rev. 2011. PMID: 21483949 Review.

6

Unique Michael addition-initiated domino reaction for the stereoselective synthesis of functionalized macrolactones from alpha-nitroketones in water.

Giorgi G, Miranda S, López-Alvarado P, Avendaño C, Rodriguez J, Menéndez JC. Giorgi G, et al. Org Lett. 2005 May 26;7(11):2197-200. doi: 10.1021/ol0505860. Org Lett. 2005. PMID: 15901168

7

Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.

Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A. Cappelli A, et al. Among authors: giorgi g. J Med Chem. 1999 May 6;42(9):1556-75. doi: 10.1021/jm981112s. J Med Chem. 1999. PMID: 10229626

8

New short strategy for the synthesis of the dibenz[b,f]oxepin scaffold.

Moreno DR, Giorgi G, Salas CO, Tapia RA. Moreno DR, et al. Among authors: giorgi g. Molecules. 2013 Nov 29;18(12):14797-806. doi: 10.3390/molecules181214797. Molecules. 2013. PMID: 24352054 Free PMC article.

9

Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.

Anzini M, Cappelli A, Vomero S, Giorgi G, Langer T, Hamon M, Merahi N, Emerit BM, Cagnotto A, Skorupska M, et al. Anzini M, et al. Among authors: giorgi g. J Med Chem. 1995 Jul 7;38(14):2692-704. doi: 10.1021/jm00014a021. J Med Chem. 1995. PMID: 7629808

10

Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.

Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C. Pellicciari R, et al. Among authors: giorgi g. J Med Chem. 1996 May 24;39(11):2259-69. doi: 10.1021/jm960059+. J Med Chem. 1996. PMID: 8667369

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