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Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells.
André MC, Erbacher A, Gille C, Schmauke V, Goecke B, Hohberger A, Mang P, Wilhelm A, Mueller I, Herr W, Lang P, Handgretinger R, Hartwig UF. André MC, et al. Among authors: handgretinger r. J Immunol. 2010 Sep 1;185(5):2710-20. doi: 10.4049/jimmunol.1000583. Epub 2010 Jul 28. J Immunol. 2010. PMID: 20668220
Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
Bugl S, Wirths S, Radsak MP, Schild H, Stein P, André MC, Müller MR, Malenke E, Wiesner T, Märklin M, Frick JS, Handgretinger R, Rammensee HG, Kanz L, Kopp HG. Bugl S, et al. Among authors: handgretinger r. Blood. 2013 Jan 31;121(5):723-33. doi: 10.1182/blood-2012-05-429589. Epub 2012 Dec 5. Blood. 2013. PMID: 23223360 Free article.
Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.
Mays LE, Ammon-Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller-Hermelink ES, Grimm M, Mezger M, Beer-Hammer S, von Stebut E, Rieber N, Nürnberg B, Schwab M, Handgretinger R, Idzko M, Hartl D, Kormann MS. Mays LE, et al. Among authors: handgretinger r. J Clin Invest. 2013 Mar;123(3):1216-28. doi: 10.1172/JCI65351. Epub 2013 Feb 8. J Clin Invest. 2013. PMID: 23391720 Free PMC article.
KIR haplotype B donors but not KIR-ligand mismatch result in a reduced incidence of relapse after haploidentical transplantation using reduced intensity conditioning and CD3/CD19-depleted grafts.
Michaelis SU, Mezger M, Bornhäuser M, Trenschel R, Stuhler G, Federmann B, Oevermann L, Kanz L, Handgretinger R, Bethge WA. Michaelis SU, et al. Among authors: handgretinger r. Ann Hematol. 2014 Sep;93(9):1579-86. doi: 10.1007/s00277-014-2084-2. Epub 2014 Apr 26. Ann Hematol. 2014. PMID: 24771045 Clinical Trial.
Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice.
Kübler A, Woiterski J, Witte KE, Bühring HJ, Hartwig UF, Ebinger M, Oevermann L, Mezger M, Herr W, Lang P, Handgretinger R, Münz C, André MC. Kübler A, et al. Among authors: handgretinger r. Blood. 2014 Dec 18;124(26):3914-23. doi: 10.1182/blood-2014-05-572743. Epub 2014 Oct 30. Blood. 2014. PMID: 25359989 Free article.
544 results