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Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.
Pharmaceutics. 2022 Jan 15;14(1):200. doi: 10.3390/pharmaceutics14010200.
Pharmaceutics. 2022.
PMID: 35057094
Free PMC article.
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
Kuespert S, Heydn R, Peters S, Wirkert E, Meyer AL, Siebörger M, Johannesen S, Aigner L, Bogdahn U, Bruun TH.
Kuespert S, et al. Among authors: wirkert e.
Int J Mol Sci. 2020 Mar 12;21(6):1952. doi: 10.3390/ijms21061952.
Int J Mol Sci. 2020.
PMID: 32178467
Free PMC article.
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Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain.
Kozole J, Heydn R, Wirkert E, Küspert S, Aigner L, Bruun TH, Bogdahn U, Peters S, Johannesen S.
Kozole J, et al. Among authors: wirkert e.
Pharmaceutics. 2022 Sep 2;14(9):1858. doi: 10.3390/pharmaceutics14091858.
Pharmaceutics. 2022.
PMID: 36145606
Free PMC article.
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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling.
Peters S, Kuespert S, Wirkert E, Heydn R, Jurek B, Johannesen S, Hsam O, Korte S, Ludwig FT, Mecklenburg L, Mrowetz H, Altendorfer B, Poupardin R, Petri S, Thal DR, Hermann A, Weishaupt JH, Weis J, Aksoylu IS, Lewandowski SA, Aigner L, Bruun TH, Bogdahn U.
Peters S, et al. Among authors: wirkert e.
Neurotherapeutics. 2021 Jul;18(3):1963-1979. doi: 10.1007/s13311-021-01045-2. Epub 2021 Apr 15.
Neurotherapeutics. 2021.
PMID: 33860461
Free PMC article.
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Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis.
Johannesen S, Huie JR, Budeus B, Peters S, Wirth AM, Iberl S, Kammermaier T, Kobor I, Wirkert E, Küspert S, Tahedl M, Grassinger J, Pukrop T, Schneider A, Aigner L, Schulte-Mattler W, Schuierer G, Koch W, Bruun TH, Ferguson AR, Bogdahn U.
Johannesen S, et al. Among authors: wirkert e.
Front Neurol. 2021 Mar 18;12:616289. doi: 10.3389/fneur.2021.616289. eCollection 2021.
Front Neurol. 2021.
PMID: 33815246
Free PMC article.
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Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients.
Johannesen S, Budeus B, Peters S, Iberl S, Meyer AL, Kammermaier T, Wirkert E, Bruun TH, Samara VC, Schulte-Mattler W, Herr W, Schneider A, Grassinger J, Bogdahn U.
Johannesen S, et al. Among authors: wirkert e.
Front Neurol. 2018 Nov 26;9:971. doi: 10.3389/fneur.2018.00971. eCollection 2018.
Front Neurol. 2018.
PMID: 30534107
Free PMC article.
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Sensory contact to the stressor prevents recovery from structural and functional heart damage following psychosocial trauma.
Foertsch S, Lackner I, Weber B, Füchsl AM, Langgartner D, Wirkert E, Peters S, Fois G, Pressmar J, Fegert JM, Frick M, Gündel H, Kalbitz M, Reber SO.
Foertsch S, et al. Among authors: wirkert e.
Brain Behav Immun. 2019 Aug;80:667-677. doi: 10.1016/j.bbi.2019.05.013. Epub 2019 May 11.
Brain Behav Immun. 2019.
PMID: 31085218
Free article.
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