Yan NL - Search Results

1

Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.

Yan NL, Nair R, Chu A, Wilson IA, Johnson KA, Morgan GJ, Kelly JW. Yan NL, et al. Bioorg Med Chem Lett. 2022 Mar 15;60:128571. doi: 10.1016/j.bmcl.2022.128571. Epub 2022 Jan 19. Bioorg Med Chem Lett. 2022. PMID: 35065233 Free PMC article.

2

Stabilization of amyloidogenic immunoglobulin light chains by small molecules.

Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW. Morgan GJ, et al. Among authors: yan nl. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8360-8369. doi: 10.1073/pnas.1817567116. Epub 2019 Apr 10. Proc Natl Acad Sci U S A. 2019. PMID: 30971495 Free PMC article.

3

The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains.

Rennella E, Morgan GJ, Yan N, Kelly JW, Kay LE. Rennella E, et al. J Am Chem Soc. 2019 Aug 28;141(34):13562-13571. doi: 10.1021/jacs.9b05499. Epub 2019 Aug 14. J Am Chem Soc. 2019. PMID: 31364359 Free PMC article.

4

Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.

Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Yan NL, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127356. doi: 10.1016/j.bmcl.2020.127356. Epub 2020 Jun 16. Bioorg Med Chem Lett. 2020. PMID: 32631553 Free PMC article.

5

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW. Yan NL, et al. J Med Chem. 2021 May 13;64(9):6273-6299. doi: 10.1021/acs.jmedchem.1c00339. Epub 2021 May 3. J Med Chem. 2021. PMID: 33939422 Free PMC article.

6

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.

Yan NL, Morgan GJ, Petrassi HM, Wilson IA, Kelly JW. Yan NL, et al. Curr Opin Chem Biol. 2023 Aug;75:102319. doi: 10.1016/j.cbpa.2023.102319. Epub 2023 Jun 6. Curr Opin Chem Biol. 2023. PMID: 37279624 Review.

7

Post-Translational Backbone Engineering through Selenomethionine-Mediated Incorporation of Freidinger Lactams.

Flood DT, Yan NL, Dawson PE. Flood DT, et al. Among authors: yan nl. Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8697-8701. doi: 10.1002/anie.201804885. Epub 2018 Jun 11. Angew Chem Int Ed Engl. 2018. PMID: 29797386 Free PMC article.

8

The conformational landscape of human transthyretin revealed by cryo-EM.

Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC. Basanta B, et al. Among authors: yan nl. bioRxiv [Preprint]. 2024 Jan 23:2024.01.23.576879. doi: 10.1101/2024.01.23.576879. bioRxiv. 2024. PMID: 38328110 Free PMC article. Preprint.

9

Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23.

Ting SY, Yan NL, Schilke BA, Craig EA. Ting SY, et al. Among authors: yan nl. Elife. 2017 Apr 25;6:e23609. doi: 10.7554/eLife.23609. Elife. 2017. PMID: 28440746 Free PMC article.

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