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Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE.
J Biol Chem. 2022 Mar;298(3):101629. doi: 10.1016/j.jbc.2022.101629. Epub 2022 Jan 24.
J Biol Chem. 2022.
PMID: 35085556
Free PMC article.
Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening.
Work HM, Kandel SE, Lampe JN.
Work HM, et al.
Sci Rep. 2021 Sep 30;11(1):19443. doi: 10.1038/s41598-021-98219-x.
Sci Rep. 2021.
PMID: 34593846
Free PMC article.
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Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement.
Hvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JN.
Hvizdak M, et al. Among authors: work hm.
J Inorg Biochem. 2023 Mar;240:112120. doi: 10.1016/j.jinorgbio.2023.112120. Epub 2023 Jan 4.
J Inorg Biochem. 2023.
PMID: 36638633
Free PMC article.
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HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation.
Work HM, Hackett JC, Lampe JN.
Work HM, et al.
Drug Metab Dispos. 2024 May 16;52(6):516-525. doi: 10.1124/dmd.123.001434.
Drug Metab Dispos. 2024.
PMID: 38267095
Free PMC article.
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Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5.
Work HM, Kandel SE, Lampe JN.
Work HM, et al.
Drug Metab Dispos. 2024 May 3:DMD-AR-2023-001598. doi: 10.1124/dmd.124.001598. Online ahead of print.
Drug Metab Dispos. 2024.
PMID: 38702193
Free article.
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Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System.
Sanders AB, Zangaro JT, Webber NK, Calhoun RP, Richards EA, Ricci SL, Work HM, Yang DD, Casey KR, Iovine JC, Baker G, Douglas TV, Dutko SB, Fasano TJ, Lofland SA, Rajan AA, Vasile MA, Carone BR, Nucci NV.
Sanders AB, et al. Among authors: work hm.
Molecules. 2022 Feb 27;27(5):1572. doi: 10.3390/molecules27051572.
Molecules. 2022.
PMID: 35268673
Free PMC article.
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