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The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg.
McElroy DL, Roebuck AJ, Greba Q, Garai S, Brandt AL, Yilmaz O, Cain SM, Snutch TP, Thakur GA, Laprairie RB, Howland JG. McElroy DL, et al. Among authors: snutch tp. IBRO Neurosci Rep. 2022 Jan 24;12:121-130. doi: 10.1016/j.ibneur.2022.01.006. eCollection 2022 Jun. IBRO Neurosci Rep. 2022. PMID: 35128516 Free PMC article.
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy.
Powell KL, Cain SM, Ng C, Sirdesai S, David LS, Kyi M, Garcia E, Tyson JR, Reid CA, Bahlo M, Foote SJ, Snutch TP, O'Brien TJ. Powell KL, et al. Among authors: snutch tp. J Neurosci. 2009 Jan 14;29(2):371-80. doi: 10.1523/JNEUROSCI.5295-08.2009. J Neurosci. 2009. PMID: 19144837 Free PMC article.
Voltage-gated calcium channels and disease.
Cain SM, Snutch TP. Cain SM, et al. Among authors: snutch tp. Biofactors. 2011 May-Jun;37(3):197-205. doi: 10.1002/biof.158. Biofactors. 2011. PMID: 21698699 Review.
T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.
Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL, Jones NC, Braine E, Rind G, Fee-Maki M, Parker D, Pajouhesh H, Parmar M, O'Brien TJ, Snutch TP. Tringham E, et al. Among authors: snutch tp. Sci Transl Med. 2012 Feb 15;4(121):121ra19. doi: 10.1126/scitranslmed.3003120. Sci Transl Med. 2012. PMID: 22344687
198 results