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Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration.
Ochoa-Alvarez JA, Krishnan H, Shen Y, Acharya NK, Han M, McNulty DE, Hasegawa H, Hyodo T, Senga T, Geng JG, Kosciuk M, Shin SS, Goydos JS, Temiakov D, Nagele RG, Goldberg GS. Ochoa-Alvarez JA, et al. Among authors: shen y. PLoS One. 2012;7(7):e41845. doi: 10.1371/journal.pone.0041845. Epub 2012 Jul 23. PLoS One. 2012. PMID: 22844530 Free PMC article.
Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility.
Krishnan H, Ochoa-Alvarez JA, Shen Y, Nevel E, Lakshminarayanan M, Williams MC, Ramirez MI, Miller WT, Goldberg GS. Krishnan H, et al. Among authors: shen y. J Biol Chem. 2013 Apr 26;288(17):12215-21. doi: 10.1074/jbc.C112.446823. Epub 2013 Mar 25. J Biol Chem. 2013. PMID: 23530051 Free PMC article.
Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms.
Ochoa-Alvarez JA, Krishnan H, Pastorino JG, Nevel E, Kephart D, Lee JJ, Retzbach EP, Shen Y, Fatahzadeh M, Baredes S, Kalyoussef E, Honma M, Adelson ME, Kaneko MK, Kato Y, Young MA, Deluca-Rapone L, Shienbaum AJ, Yin K, Jensen LD, Goldberg GS. Ochoa-Alvarez JA, et al. Among authors: shen y. Oncotarget. 2015 Apr 20;6(11):9045-60. doi: 10.18632/oncotarget.3515. Oncotarget. 2015. PMID: 25826087 Free PMC article.
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