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DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells.
Seredinski S, Boos F, Günther S, Oo JA, Warwick T, Izquierdo Ponce J, Lillich FF, Proschak E, Knapp S, Gilsbach R, Pflüger-Müller B, Brandes RP, Leisegang MS. Seredinski S, et al. Among authors: knapp s. Mol Ther Nucleic Acids. 2022 Jan 25;27:1023-1035. doi: 10.1016/j.omtn.2022.01.016. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2022. PMID: 35228897 Free PMC article.
Thermodynamic properties of leukotriene A4 hydrolase inhibitors.
Wittmann SK, Kalinowsky L, Kramer JS, Bloecher R, Knapp S, Steinhilber D, Pogoryelov D, Proschak E, Heering J. Wittmann SK, et al. Among authors: knapp s. Bioorg Med Chem. 2016 Nov 1;24(21):5243-5248. doi: 10.1016/j.bmc.2016.08.047. Epub 2016 Aug 26. Bioorg Med Chem. 2016. PMID: 27651294
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. Kramer JS, et al. Among authors: knapp s. J Med Chem. 2019 Sep 26;62(18):8443-8460. doi: 10.1021/acs.jmedchem.9b00445. Epub 2019 Sep 17. J Med Chem. 2019. PMID: 31436984 Free PMC article.
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode.
Hanke T, Cheung SY, Kilu W, Heering J, Ni X, Planz V, Schierle S, Faudone G, Friedrich M, Wanior M, Werz O, Windbergs M, Proschak E, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Merk D. Hanke T, et al. Among authors: knapp s. J Med Chem. 2020 May 14;63(9):4555-4561. doi: 10.1021/acs.jmedchem.9b01786. Epub 2020 Apr 20. J Med Chem. 2020. PMID: 32267688
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D. Gellrich L, et al. Among authors: knapp s. J Med Chem. 2020 Jul 9;63(13):6727-6740. doi: 10.1021/acs.jmedchem.9b02150. Epub 2020 Jun 4. J Med Chem. 2020. PMID: 32356658
Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.
Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. Bibli SI, et al. Among authors: knapp s. Circulation. 2021 Mar 2;143(9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877. Epub 2020 Dec 14. Circulation. 2021. PMID: 33307764
Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator.
Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E. Hartmann M, et al. Among authors: knapp s. J Med Chem. 2021 Mar 11;64(5):2815-2828. doi: 10.1021/acs.jmedchem.0c02063. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33620196
Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.
Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E. Hartmann M, et al. Among authors: knapp s. J Med Chem. 2021 Apr 8;64(7):3720-3746. doi: 10.1021/acs.jmedchem.0c01564. Epub 2021 Mar 26. J Med Chem. 2021. PMID: 33769048
1,285 results