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The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity.
Petit GA, Hong Y, Djoko KY, Whitten AE, Furlong EJ, McCoy AJ, Gulbis JM, Totsika M, Martin JL, Halili MA. Petit GA, et al. Among authors: totsika m. Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):337-352. doi: 10.1107/S2059798322000729. Epub 2022 Feb 21. Acta Crystallogr D Struct Biol. 2022. PMID: 35234148 Free PMC article.
DSB proteins and bacterial pathogenicity.
Heras B, Shouldice SR, Totsika M, Scanlon MJ, Schembri MA, Martin JL. Heras B, et al. Among authors: totsika m. Nat Rev Microbiol. 2009 Mar;7(3):215-25. doi: 10.1038/nrmicro2087. Epub 2009 Feb 9. Nat Rev Microbiol. 2009. PMID: 19198617 Review.
Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA.
Adams LA, Sharma P, Mohanty B, Ilyichova OV, Mulcair MD, Williams ML, Gleeson EC, Totsika M, Doak BC, Caria S, Rimmer K, Horne J, Shouldice SR, Vazirani M, Headey SJ, Plumb BR, Martin JL, Heras B, Simpson JS, Scanlon MJ. Adams LA, et al. Among authors: totsika m. Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2179-84. doi: 10.1002/anie.201410341. Epub 2014 Dec 30. Angew Chem Int Ed Engl. 2015. PMID: 25556635
Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens.
Totsika M, Vagenas D, Paxman JJ, Wang G, Dhouib R, Sharma P, Martin JL, Scanlon MJ, Heras B. Totsika M, et al. Antioxid Redox Signal. 2018 Sep 1;29(7):653-666. doi: 10.1089/ars.2017.7104. Epub 2018 Feb 1. Antioxid Redox Signal. 2018. PMID: 29237285 Free PMC article.
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX).
Bentley MR, Ilyichova OV, Wang G, Williams ML, Sharma G, Alwan WS, Whitehouse RL, Mohanty B, Scammells PJ, Heras B, Martin JL, Totsika M, Capuano B, Doak BC, Scanlon MJ. Bentley MR, et al. Among authors: totsika m. J Med Chem. 2020 Jul 9;63(13):6863-6875. doi: 10.1021/acs.jmedchem.0c00111. Epub 2020 Jun 24. J Med Chem. 2020. PMID: 32529824
107 results