Schilling S - Search Results

1

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice.

Gnoth K, Geissler S, Feldhaus J, Taudte N, Ilse V, Zürner S, Greiser S, Braumann UD, Rahfeld JU, Cynis H, Schilling S. Gnoth K, et al. Among authors: schilling s. Biomolecules. 2022 Mar 4;12(3):399. doi: 10.3390/biom12030399. Biomolecules. 2022. PMID: 35327591 Free PMC article.

2

Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.

Schilling S, Niestroj AJ, Rahfeld JU, Hoffmann T, Wermann M, Zunkel K, Wasternack C, Demuth HU. Schilling S, et al. J Biol Chem. 2003 Dec 12;278(50):49773-9. doi: 10.1074/jbc.M309077200. Epub 2003 Sep 30. J Biol Chem. 2003. PMID: 14522962 Free article.

3

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, Demuth HU. Schilling S, et al. Biochemistry. 2005 Oct 11;44(40):13415-24. doi: 10.1021/bi051142e. Biochemistry. 2005. PMID: 16201766

4

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU. Cynis H, et al. Among authors: schilling s. Biochim Biophys Acta. 2006 Oct;1764(10):1618-25. doi: 10.1016/j.bbapap.2006.08.003. Epub 2006 Aug 16. Biochim Biophys Acta. 2006. PMID: 17005457

5

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, Demuth HU. Schilling S, et al. Biochemistry. 2007 Sep 25;46(38):10921-30. doi: 10.1021/bi701043x. Epub 2007 Aug 28. Biochemistry. 2007. PMID: 17722885

6

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S. Cynis H, et al. Among authors: schilling s. J Mol Biol. 2008 Jun 20;379(5):966-80. doi: 10.1016/j.jmb.2008.03.078. Epub 2008 Apr 15. J Mol Biol. 2008. PMID: 18486145

7

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.

Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU. Cynis H, et al. Among authors: schilling s. Biochemistry. 2008 Jul 15;47(28):7405-13. doi: 10.1021/bi800250p. Epub 2008 Jun 21. Biochemistry. 2008. PMID: 18570439

8

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU. Schilling S, et al. J Neurochem. 2008 Aug;106(3):1225-36. doi: 10.1111/j.1471-4159.2008.05471.x. Epub 2008 Jul 8. J Neurochem. 2008. PMID: 18627432 Free article.

9

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S. Schilling S, et al. Nat Med. 2008 Oct;14(10):1106-11. doi: 10.1038/nm.1872. Epub 2008 Sep 28. Nat Med. 2008. PMID: 18836460

10

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.

Wirths O, Breyhan H, Cynis H, Schilling S, Demuth HU, Bayer TA. Wirths O, et al. Among authors: schilling s. Acta Neuropathol. 2009 Oct;118(4):487-96. doi: 10.1007/s00401-009-0557-5. Epub 2009 Jun 23. Acta Neuropathol. 2009. PMID: 19547991 Free PMC article.

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