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Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.
Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, Borchelt DR. Moore BD, et al. Free Neuropathol. 2022 Jan 11;3(9):3-9. doi: 10.17879/freeneuropathology-2022-3766. Epub 2022 Mar 23. Free Neuropathol. 2022. PMID: 35494163 Free PMC article.
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, Younkin SG, Graff-Radford N, Dickson D, Rosenberry T, Golde TE. Kim J, et al. Among authors: moore bd. J Neurosci. 2008 Jun 4;28(23):6030-6. doi: 10.1523/JNEUROSCI.0891-08.2008. J Neurosci. 2008. PMID: 18524908 Free PMC article.
Substrate-targeting gamma-secretase modulators.
Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE. Kukar TL, et al. J Biol Chem. 2011 Nov 18;286(46):39804-12. doi: 10.1074/jbc.M111.274696. Epub 2011 Aug 25. J Biol Chem. 2011. PMID: 21868378 Free PMC article.
Steroids as γ-secretase modulators.
Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Jung JI, et al. Among authors: moore bd. FASEB J. 2013 Sep;27(9):3775-85. doi: 10.1096/fj.12-225649. Epub 2013 May 28. FASEB J. 2013. PMID: 23716494 Free PMC article.
225 results