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Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro.
Paranjape SR, Riley AP, Somoza AD, Oakley CE, Wang CC, Prisinzano TE, Oakley BR, Gamblin TC. Paranjape SR, et al. Among authors: riley ap. ACS Chem Neurosci. 2015 May 20;6(5):751-60. doi: 10.1021/acschemneuro.5b00013. Epub 2015 Apr 15. ACS Chem Neurosci. 2015. PMID: 25822288 Free PMC article.
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability.
Crowley RS, Riley AP, Sherwood AM, Groer CE, Shivaperumal N, Biscaia M, Paton K, Schneider S, Provasi D, Kivell BM, Filizola M, Prisinzano TE. Crowley RS, et al. Among authors: riley ap. J Med Chem. 2016 Dec 22;59(24):11027-11038. doi: 10.1021/acs.jmedchem.6b01235. Epub 2016 Dec 13. J Med Chem. 2016. PMID: 27958743 Free PMC article.
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor.
Crowley RS, Riley AP, Alder AF, Anderson RJ 3rd, Luo D, Kaska S, Maynez P, Kivell BM, Prisinzano TE. Crowley RS, et al. Among authors: riley ap. ACS Chem Neurosci. 2020 Jun 17;11(12):1781-1790. doi: 10.1021/acschemneuro.0c00191. Epub 2020 May 26. ACS Chem Neurosci. 2020. PMID: 32383854 Free PMC article.
24 results