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The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress.
Sagliocchi S, Cicatiello AG, Di Cicco E, Ambrosio R, Miro C, Di Girolamo D, Nappi A, Mancino G, De Stefano MA, Luongo C, Raia M, Ogawa-Wong AN, Zavacki AM, Paladino S, Salvatore D, Dentice M. Sagliocchi S, et al. Among authors: raia m. Redox Biol. 2019 Jun;24:101228. doi: 10.1016/j.redox.2019.101228. Epub 2019 May 22. Redox Biol. 2019. PMID: 31153038 Free PMC article.
Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage.
Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M. Nappi A, et al. Among authors: raia m. Nat Commun. 2023 Mar 4;14(1):1244. doi: 10.1038/s41467-023-36755-y. Nat Commun. 2023. PMID: 36871014 Free PMC article.
Role of Dicer1 in thyroid cell proliferation and differentiation.
Penha RCC, Sepe R, De Martino M, Esposito F, Pellecchia S, Raia M, Del Vecchio L, Decaussin-Petrucci M, De Vita G, Pinto LFR, Fusco A. Penha RCC, et al. Among authors: raia m. Cell Cycle. 2017;16(23):2282-2289. doi: 10.1080/15384101.2017.1380127. Epub 2017 Nov 9. Cell Cycle. 2017. PMID: 28933615 Free PMC article.
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