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Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis.
Chen X, Zhi X, Pan P, Cui J, Cao L, Weng W, Zhou Q, Wang L, Zhai X, Zhao Q, Hu H, Huang B, Su J. Chen X, et al. Among authors: su j. FASEB J. 2017 Nov;31(11):4855-4865. doi: 10.1096/fj.201700316R. Epub 2017 Jul 24. FASEB J. 2017. PMID: 28739641 Free PMC article.
Our study demonstrates that matrine inhibits osteoclastogenesis through modulation of multiple pathways and that matrine is a promising agent in the treatment of osteoclast-related diseases such as osteoporosis.-Chen, X., Zhi, X., Pan, P., Cui, J., Cao, L., Weng, W., Zhou, …
Our study demonstrates that matrine inhibits osteoclastogenesis through modulation of multiple pathways and that matrine is a promising agen …
Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis.
Chen X, Zhi X, Cao L, Weng W, Pan P, Hu H, Liu C, Zhao Q, Zhou Q, Cui J, Su J. Chen X, et al. Among authors: su j. Cell Death Dis. 2017 Sep 7;8(9):e3037. doi: 10.1038/cddis.2017.394. Cell Death Dis. 2017. Retraction in: Cell Death Dis. 2022 Mar 11;13(3):225. doi: 10.1038/s41419-022-04697-w. PMID: 28880271 Free PMC article. Retracted.
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