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Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice.
Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: edwards mj. J Biol Chem. 2022 Aug;298(8):102185. doi: 10.1016/j.jbc.2022.102185. Epub 2022 Jun 24. J Biol Chem. 2022. PMID: 35753355 Free PMC article.
Sphingolipids in Major Depression.
Jernigan PL, Hoehn RS, Grassmé H, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Jernigan PL, et al. Among authors: edwards mj. Neurosignals. 2015;23(1):49-58. doi: 10.1159/000442603. Epub 2015 Dec 19. Neurosignals. 2015. PMID: 26684792 Free article. Review.
Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.
Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Gulbins A, et al. Among authors: edwards mj. Mol Psychiatry. 2018 Dec;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9. Epub 2018 Jul 23. Mol Psychiatry. 2018. PMID: 30038230 Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma.
Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: edwards mj. J Mol Med (Berl). 2022 Oct;100(10):1493-1508. doi: 10.1007/s00109-022-02250-y. Epub 2022 Aug 31. J Mol Med (Berl). 2022. PMID: 36045177 Free PMC article.
1,027 results