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Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice.
Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: wilson gc. J Biol Chem. 2022 Aug;298(8):102185. doi: 10.1016/j.jbc.2022.102185. Epub 2022 Jun 24. J Biol Chem. 2022. PMID: 35753355 Free PMC article.
Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice.
Quillin RC 3rd, Wilson GC, Nojima H, Freeman CM, Wang J, Schuster RM, Blanchard JA, Edwards MJ, Gandhi CR, Gulbins E, Lentsch AB. Quillin RC 3rd, et al. Among authors: wilson gc. Hepatol Res. 2015 Mar;45(3):305-14. doi: 10.1111/hepr.12352. Epub 2014 Jun 4. Hepatol Res. 2015. PMID: 24796378 Free PMC article.
Characterization of microparticles after hepatic ischemia-reperfusion injury.
Freeman CM, Quillin RC 3rd, Wilson GC, Nojima H, Johnson BL 3rd, Sutton JM, Schuster RM, Blanchard J, Edwards MJ, Caldwell CC, Lentsch AB. Freeman CM, et al. Among authors: wilson gc. PLoS One. 2014 May 30;9(5):e97945. doi: 10.1371/journal.pone.0097945. eCollection 2014. PLoS One. 2014. PMID: 24879335 Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. Among authors: wilson gc. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Becker KA, Verhaegh R, Verhasselt HL, Keitsch S, Soddemann M, Wilker B, Wilson GC, Buer J, Ahmad SA, Edwards MJ, Gulbins E. Becker KA, et al. Among authors: wilson gc. Infect Immun. 2021 Jan 19;89(2):e00677-20. doi: 10.1128/IAI.00677-20. Print 2021 Jan 19. Infect Immun. 2021. PMID: 33139382 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: wilson gc. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model.
Li W, Wilson GC, Bachmann M, Wang J, Mattarei A, Paradisi C, Edwards MJ, Szabo I, Gulbins E, Ahmad SA, Patel SH. Li W, et al. Among authors: wilson gc. Cancers (Basel). 2022 May 25;14(11):2618. doi: 10.3390/cancers14112618. Cancers (Basel). 2022. PMID: 35681598 Free PMC article.
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma.
Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: wilson gc. J Mol Med (Berl). 2022 Oct;100(10):1493-1508. doi: 10.1007/s00109-022-02250-y. Epub 2022 Aug 31. J Mol Med (Berl). 2022. PMID: 36045177 Free PMC article.
143 results