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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Baldwin ET, Götte M, Tchesnokov EP, Arnold E, Hagel M, Nichols C, Dossang P, Lamers M, Wan P, Steinbacher S, Romero DL. Baldwin ET, et al. Among authors: hagel m. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2200260119. doi: 10.1073/pnas.2200260119. Epub 2022 Jun 30. Proc Natl Acad Sci U S A. 2022. PMID: 35771941 Free PMC article.
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M. Ryan MB, et al. Among authors: hagel m. Cancer Discov. 2024 Apr 8. doi: 10.1158/2159-8290.CD-24-0139. Online ahead of print. Cancer Discov. 2024. PMID: 38588399
Inducing Mechanical Stimuli to Tissues Grown on a Magnetic Gel Allows Deconvoluting the Forces Leading to Traumatic Brain Injury.
Schlotterose L, Beldjilali-Labro M, Hagel M, Yadid M, Flaxer C, Flaxer E, Barnea AR, Hattermann K, Shohami E, Leichtmann-Bardoogo Y, Maoz BM. Schlotterose L, et al. Among authors: hagel m. Neurotrauma Rep. 2023 Aug 23;4(1):560-572. doi: 10.1089/neur.2023.0026. eCollection 2023. Neurotrauma Rep. 2023. PMID: 37636339 Free PMC article.
A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films.
Yadid M, Hagel M, Labro MB, Le Roi B, Flaxer C, Flaxer E, Barnea AR, Tejman-Yarden S, Silberman E, Li X, Rauti R, Leichtmann-Bardoogo Y, Yuan H, Maoz BM. Yadid M, et al. Among authors: hagel m. Adv Sci (Weinh). 2023 Sep;10(27):e2207498. doi: 10.1002/advs.202207498. Epub 2023 Jul 23. Adv Sci (Weinh). 2023. PMID: 37485582 Free PMC article.
FOXG1 targets BMP repressors and cell cycle inhibitors in human neural progenitor cells.
Hettige NC, Fleming P, Semenak A, Zhang X, Peng H, Hagel MD, Théroux JF, Zhang Y, Ni A, Jefri M, Antonyan L, Alsuwaidi S, Schuppert A, Stumpf PS, Ernst C. Hettige NC, et al. Among authors: hagel md. Hum Mol Genet. 2023 Jul 20;32(15):2511-2522. doi: 10.1093/hmg/ddad089. Hum Mol Genet. 2023. PMID: 37216650 Free PMC article.
Ethical research engagement with Indigenous communities.
Billan J, Starblanket D, Anderson S, Legare M, Hagel MC, Oakes N, Jardine M, Boehme G, Dubois E, Spencer O, Hotomani M, McKenna B, Bourassa C. Billan J, et al. Among authors: hagel mc. J Rehabil Assist Technol Eng. 2020 Jun 22;7:2055668320922706. doi: 10.1177/2055668320922706. eCollection 2020 Jan-Dec. J Rehabil Assist Technol Eng. 2020. PMID: 32612848 Free PMC article.
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