Hellyer SD - Search Results

1

Adenosine receptor signalling in Alzheimer's disease.

Trinh PNH, Baltos JA, Hellyer SD, May LT, Gregory KJ. Trinh PNH, et al. Among authors: hellyer sd. Purinergic Signal. 2022 Sep;18(3):359-381. doi: 10.1007/s11302-022-09883-1. Epub 2022 Jul 23. Purinergic Signal. 2022. PMID: 35870032 Free PMC article. Review.

2

Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.

Hellyer S, Leach K, Gregory KJ. Hellyer S, et al. Curr Opin Pharmacol. 2017 Feb;32:49-55. doi: 10.1016/j.coph.2016.10.007. Epub 2016 Nov 11. Curr Opin Pharmacol. 2017. PMID: 27842256 Review.

3

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu₅ Allosteric Ligands.

Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ. Hellyer SD, et al. Mol Pharmacol. 2018 May;93(5):504-514. doi: 10.1124/mol.117.111518. Epub 2018 Mar 7. Mol Pharmacol. 2018. PMID: 29514854

4

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.

Sengmany K, Hellyer SD, Albold S, Wang T, Conn PJ, May LT, Christopoulos A, Leach K, Gregory KJ. Sengmany K, et al. Among authors: hellyer sd. Neuropharmacology. 2019 May 1;149:83-96. doi: 10.1016/j.neuropharm.2019.02.005. Epub 2019 Feb 11. Neuropharmacology. 2019. PMID: 30763654 Free PMC article.

5

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5.

Chen ANY, Hellyer SD, Trinh PNH, Leach K, Gregory KJ. Chen ANY, et al. Among authors: hellyer sd. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6:104-115. doi: 10.1111/bcpt.13239. Epub 2019 May 7. Basic Clin Pharmacol Toxicol. 2020. PMID: 30983151 Free article.

6

Metabotropic glutamate receptor 5 (mGlu₅ )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu₅ signaling in recombinant cells and neurons.

Hellyer SD, Albold S, Sengmany K, Singh J, Leach K, Gregory KJ. Hellyer SD, et al. J Neurochem. 2019 Nov;151(3):301-315. doi: 10.1111/jnc.14844. Epub 2019 Aug 26. J Neurochem. 2019. PMID: 31376155 Free article.

7

Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism.

Sengmany K, Hellyer SD, Christopoulos A, Lapinsky DJ, Leach K, Gregory KJ. Sengmany K, et al. Among authors: hellyer sd. Biochem Pharmacol. 2020 Jul;177:114011. doi: 10.1016/j.bcp.2020.114011. Epub 2020 May 5. Biochem Pharmacol. 2020. PMID: 32380090

8

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site.

Hellyer SD, Sengmany K, Keller AN, Christopoulos A, Leach K, Gregory KJ. Hellyer SD, et al. Biochem Pharmacol. 2020 Jul;177:114013. doi: 10.1016/j.bcp.2020.114013. Epub 2020 May 8. Biochem Pharmacol. 2020. PMID: 32389635

9

Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes.

Hellyer SD, Aggarwal S, Chen ANY, Leach K, Lapinsky DJ, Gregory KJ. Hellyer SD, et al. ACS Chem Neurosci. 2020 Jun 3;11(11):1597-1609. doi: 10.1021/acschemneuro.0c00009. Epub 2020 May 22. ACS Chem Neurosci. 2020. PMID: 32396330

10

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias.

Arsova A, Møller TC, Hellyer SD, Vedel L, Foster SR, Hansen JL, Bräuner-Osborne H, Gregory KJ. Arsova A, et al. Among authors: hellyer sd. Mol Pharmacol. 2021 May;99(5):328-341. doi: 10.1124/molpharm.120.000185. Epub 2021 Feb 18. Mol Pharmacol. 2021. PMID: 33602724

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