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Novel molecular, structural and clinical findings in an Italian cohort of congenital cataract.
Lecca M, Mauri L, Gana S, Del Longo A, Morelli F, Nicotra R, Plumari M, Galli J, Sirchia F, Valente EM, Cavallari U, Mazza M, Signorini S, Errichiello E. Lecca M, et al. Clin Genet. 2024 Jun 5. doi: 10.1111/cge.14568. Online ahead of print. Clin Genet. 2024. PMID: 38840272
In a further 14 probands/families a candidate variant was identified: in 12 families a VUS was detected, of which 9 were considered plausibly pathogenic (i.e., 4 or 5 points according to ACMG criteria), while in 2 probands ES identified a single variant in an autosomal rec …
In a further 14 probands/families a candidate variant was identified: in 12 families a VUS was detected, of which 9 were considered plausibl …
Targeting mTOR and survivin concurrently potentiates radiation therapy in renal cell carcinoma by suppressing DNA damage repair and amplifying mitotic catastrophe.
Rachamala HK, Madamsetty VS, Angom RS, Nakka NM, Dutta SK, Wang E, Mukhopadhyay D, Pal K. Rachamala HK, et al. J Exp Clin Cancer Res. 2024 Jun 6;43(1):159. doi: 10.1186/s13046-024-03079-8. J Exp Clin Cancer Res. 2024. PMID: 38840237
RESULTS: EY-L outperformed the corresponding single drug-loaded formulations E-L and Y-L in terms of containing primary tumor growth and improving survival in an immunocompetent syngeneic mouse model of RCC. EY-L also exhibited significantly higher sensitization of RCC cel …
RESULTS: EY-L outperformed the corresponding single drug-loaded formulations E-L and Y-L in terms of containing primary tumor growth …
E-learning platforms in ideological and political education at universities: students' motivation and learning performance.
Yang H. Yang H. BMC Med Educ. 2024 Jun 6;24(1):628. doi: 10.1186/s12909-024-05572-2. BMC Med Educ. 2024. PMID: 38840228
BACKGROUND: The study aimed to examine the impact of using the MOODLE e-learning platform in ideological and political education on Chinese students' motivation and academic performance. ...RESULTS: As a result, the significance of the motivational component in achieving t …
BACKGROUND: The study aimed to examine the impact of using the MOODLE e-learning platform in ideological and political education on C …
Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature.
Loricera J, Tofade T, Prieto-Peña D, Romero-Yuste S, de Miguel E, Riveros-Frutos A, Ferraz-Amaro I, Labrador E, Maiz O, Becerra E, Narváez J, Galíndez-Agirregoikoa E, González-Fernández I, Urruticoechea-Arana A, Ramos-Calvo Á, López-Gutiérrez F, Castañeda S, Unizony S, Blanco R. Loricera J, et al. Arthritis Res Ther. 2024 Jun 5;26(1):116. doi: 10.1186/s13075-024-03314-9. Arthritis Res Ther. 2024. PMID: 38840219
Before JAKi therapy, 22 (63%) patients had received conventional synthetic immunosuppressants (e.g., methotrexate), and 30 (86%) biologics (e.g., tocilizumab). ...
Before JAKi therapy, 22 (63%) patients had received conventional synthetic immunosuppressants (e.g., methotrexate), and 30 (86%) biol …
Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model.
Teng X, Wang Z, Wang X. Teng X, et al. J Ovarian Res. 2024 Jun 5;17(1):121. doi: 10.1186/s13048-024-01445-w. J Ovarian Res. 2024. PMID: 38840218
Morphological changes in ovarian tissue were examined by Hematoxylin and Eosin (H&E) staining, apoptosis was determined using the TUNEL assay, and CD31 expression was analyzed through immunofluorescent staining to assess angiogenic activity. RESULTS: The existence of B …
Morphological changes in ovarian tissue were examined by Hematoxylin and Eosin (H&E) staining, apoptosis was determined using the …
Development of two multiplex PCR assays for rapid detection of eleven Gram-negative bacteria in children with septicemia.
Miringu G, Musyoki A, Muriithi B, Wandera E, Waithiru D, Odoyo E, Shoji H, Menza N, Ichinose Y. Miringu G, et al. Trop Med Health. 2024 Jun 5;52(1):40. doi: 10.1186/s41182-024-00606-3. Trop Med Health. 2024. PMID: 38840209
The assays also identified Salmonella spp. and Klebsiella pneumoniae co-infections and extra pathogens (1 E. coli and 2 K. pneumoniae) compared with culture. The sensitivity and specificity of the mPCR were 100.0% (71.7-100.0) and 98.0% (90.7-99.0), respectively. ...
The assays also identified Salmonella spp. and Klebsiella pneumoniae co-infections and extra pathogens (1 E. coli and 2 K. pneumoniae …
The mutation of Japanese encephalitis virus envelope protein residue 389 attenuates viral neuroinvasiveness.
Huang R, He Y, Zhang C, Luo Y, Chen C, Tan N, Ren Y, Xu K, Yuan L, Yang J. Huang R, et al. Virol J. 2024 Jun 5;21(1):128. doi: 10.1186/s12985-024-02398-8. Virol J. 2024. PMID: 38840203
The mutation of multiple aa residues in the E protein plays a critical role in the attenuated strain of JEV. ...In contrast, less flexibility of E protein enhanced the neuroinvasiveness of the strain. Our results indicate that the mechanism of attenuation of E389 aa …
The mutation of multiple aa residues in the E protein plays a critical role in the attenuated strain of JEV. ...In contrast, less fle …
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