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Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Dong X, Limjunyawong N, Sypek EI, Wang G, Ortines RV, Youn C, Alphonse MP, Dikeman D, Wang Y, Lay M, Kothari R, Vasavda C, Pundir P, Goff L, Miller LS, Lu W, Garza LA, Kim BS, Archer NK, Dong X. Dong X, et al. Among authors: wang g, wang y. Immunity. 2022 Sep 13;55(9):1645-1662.e7. doi: 10.1016/j.immuni.2022.06.021. Epub 2022 Jul 25. Immunity. 2022. PMID: 35882236 Free PMC article.
Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.
Wang Y, Cheng LI, Helfer DR, Ashbaugh AG, Miller RJ, Tzomides AJ, Thompson JM, Ortines RV, Tsai AS, Liu H, Dillen CA, Archer NK, Cohen TS, Tkaczyk C, Stover CK, Sellman BR, Miller LS. Wang Y, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. doi: 10.1073/pnas.1703427114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607050 Free PMC article.
Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.
Ortines RV, Liu H, Cheng LI, Cohen TS, Lawlor H, Gami A, Wang Y, Dillen CA, Archer NK, Miller RJ, Ashbaugh AG, Pinsker BL, Marchitto MC, Tkaczyk C, Stover CK, Sellman BR, Miller LS. Ortines RV, et al. Among authors: wang y. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02288-17. doi: 10.1128/AAC.02288-17. Print 2018 Mar. Antimicrob Agents Chemother. 2018. PMID: 29311091 Free PMC article.
Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection.
Dillen CA, Pinsker BL, Marusina AI, Merleev AA, Farber ON, Liu H, Archer NK, Lee DB, Wang Y, Ortines RV, Lee SK, Marchitto MC, Cai SS, Ashbaugh AG, May LS, Holland SM, Freeman AF, Miller LG, Yeaman MR, Simon SI, Milner JD, Maverakis E, Miller LS. Dillen CA, et al. Among authors: wang y. J Clin Invest. 2018 Mar 1;128(3):1026-1042. doi: 10.1172/JCI96481. Epub 2018 Feb 5. J Clin Invest. 2018. PMID: 29400698 Free PMC article.
Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.
Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS. Thompson JM, et al. Among authors: wang y. JCI Insight. 2018 Sep 6;3(17):e121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6. JCI Insight. 2018. PMID: 30185667 Free PMC article.
Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release.
Archer NK, Jo JH, Lee SK, Kim D, Smith B, Ortines RV, Wang Y, Marchitto MC, Ravipati A, Cai SS, Dillen CA, Liu H, Miller RJ, Ashbaugh AG, Uppal AS, Oyoshi MK, Malhotra N, Hoff S, Garza LA, Kong HH, Segre JA, Geha RS, Miller LS. Archer NK, et al. Among authors: wang y. J Allergy Clin Immunol. 2019 Apr;143(4):1426-1443.e6. doi: 10.1016/j.jaci.2018.08.042. Epub 2018 Sep 19. J Allergy Clin Immunol. 2019. PMID: 30240702 Free PMC article.
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