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Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase.
Stroke. 2022 Oct;53(10):3235-3237. doi: 10.1161/STROKEAHA.122.040219. Epub 2022 Aug 30.
Stroke. 2022.
PMID: 36039755
Review.
Structural Biology and Protein Engineering of Thrombolytics.
Mican J, Toul M, Bednar D, Damborsky J.
Mican J, et al. Among authors: toul m.
Comput Struct Biotechnol J. 2019 Jul 2;17:917-938. doi: 10.1016/j.csbj.2019.06.023. eCollection 2019.
Comput Struct Biotechnol J. 2019.
PMID: 31360331
Free PMC article.
Review.
Item in Clipboard
Development and Testing of Thrombolytics in Stroke.
Nikitin D, Choi S, Mican J, Toul M, Ryu WS, Damborsky J, Mikulik R, Kim DE.
Nikitin D, et al. Among authors: toul m.
J Stroke. 2021 Jan;23(1):12-36. doi: 10.5853/jos.2020.03349. Epub 2021 Jan 31.
J Stroke. 2021.
PMID: 33600700
Free PMC article.
Review.
Item in Clipboard
Engineering the protein dynamics of an ancestral luciferase.
Schenkmayerova A, Pinto GP, Toul M, Marek M, Hernychova L, Planas-Iglesias J, Daniel Liskova V, Pluskal D, Vasina M, Emond S, Dörr M, Chaloupkova R, Bednar D, Prokop Z, Hollfelder F, Bornscheuer UT, Damborsky J.
Schenkmayerova A, et al. Among authors: toul m.
Nat Commun. 2021 Jun 14;12(1):3616. doi: 10.1038/s41467-021-23450-z.
Nat Commun. 2021.
PMID: 34127663
Free PMC article.
Item in Clipboard
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin.
Nikitin D, Mican J, Toul M, Bednar D, Peskova M, Kittova P, Thalerova S, Vitecek J, Damborsky J, Mikulik R, Fleishman SJ, Prokop Z, Marek M.
Nikitin D, et al. Among authors: toul m.
Comput Struct Biotechnol J. 2022 Mar 12;20:1366-1377. doi: 10.1016/j.csbj.2022.03.004. eCollection 2022.
Comput Struct Biotechnol J. 2022.
PMID: 35386102
Free PMC article.
Item in Clipboard
Identification, characterization, and engineering of glycosylation in thrombolytics.
Toul M, Slonkova V, Mican J, Urminsky A, Tomkova M, Sedlak E, Bednar D, Damborsky J, Hernychova L, Prokop Z.
Toul M, et al.
Biotechnol Adv. 2023 Sep;66:108174. doi: 10.1016/j.biotechadv.2023.108174. Epub 2023 May 12.
Biotechnol Adv. 2023.
PMID: 37182613
Review.
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Azobenzene-Based Photoswitchable Substrates for Advanced Mechanistic Studies of Model Haloalkane Dehalogenase Enzyme Family.
Slanska M, Stackova L, Marques SM, Stacko P, Martínek M, Jílek L, Toul M, Damborsky J, Bednar D, Klán P, Prokop Z.
Slanska M, et al. Among authors: toul m.
ACS Catal. 2024 Jul 22;14(15):11635-11645. doi: 10.1021/acscatal.4c03503. eCollection 2024 Aug 2.
ACS Catal. 2024.
PMID: 39114093
Free PMC article.
Item in Clipboard
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase.
Nemergut M, Pluskal D, Horackova J, Sustrova T, Tulis J, Barta T, Baatallah R, Gagnot G, Novakova V, Majerova M, Sedlackova K, Marques SM, Toul M, Damborsky J, Prokop Z, Bednar D, Janin YL, Marek M.
Nemergut M, et al. Among authors: toul m.
Nat Commun. 2023 Nov 29;14(1):7864. doi: 10.1038/s41467-023-43403-y.
Nat Commun. 2023.
PMID: 38030625
Free PMC article.
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