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Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy.
Gutwillig A, Santana-Magal N, Farhat-Younis L, Rasoulouniriana D, Madi A, Luxenburg C, Cohen J, Padmanabhan K, Shomron N, Shapira G, Gleiberman A, Parikh R, Levy C, Feinmesser M, Hershkovitz D, Zemser-Werner V, Zlotnik O, Kroon S, Hardt WD, Debets R, Reticker-Flynn NE, Rider P, Carmi Y. Gutwillig A, et al. Among authors: hardt wd. Elife. 2022 Sep 20;11:e80315. doi: 10.7554/eLife.80315. Elife. 2022. PMID: 36124553 Free PMC article.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Fattinger SA, Maurer L, Geiser P, Bernard EM, Enz U, Ganguillet S, Gül E, Kroon S, Demarco B, Mack V, Furter M, Barthel M, Pelczar P, Shao F, Broz P, Sellin ME, Hardt WD. Fattinger SA, et al. Among authors: hardt wd. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120. doi: 10.1073/pnas.2315503120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988464 Free PMC article.
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.
Stecher B, Denzler R, Maier L, Bernet F, Sanders MJ, Pickard DJ, Barthel M, Westendorf AM, Krogfelt KA, Walker AW, Ackermann M, Dobrindt U, Thomson NR, Hardt WD. Stecher B, et al. Among authors: hardt wd. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1269-74. doi: 10.1073/pnas.1113246109. Epub 2012 Jan 9. Proc Natl Acad Sci U S A. 2012. PMID: 22232693 Free PMC article.
Salmonella transiently reside in luminal neutrophils in the inflamed gut.
Loetscher Y, Wieser A, Lengefeld J, Kaiser P, Schubert S, Heikenwalder M, Hardt WD, Stecher B. Loetscher Y, et al. Among authors: hardt wd. PLoS One. 2012;7(4):e34812. doi: 10.1371/journal.pone.0034812. Epub 2012 Apr 6. PLoS One. 2012. PMID: 22493718 Free PMC article.
218 results