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TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance.
Peotter JL, Pustova I, Lettman MM, Shatadal S, Bradberry MM, Winter-Reed AD, Charan M, Sharkey EE, Alvin JR, Bren AM, Oie AK, Chapman ER, Salamat MS, Audhya A. Peotter JL, et al. Among authors: audhya a. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210649119. doi: 10.1073/pnas.2210649119. Epub 2022 Sep 26. Proc Natl Acad Sci U S A. 2022. PMID: 36161950 Free PMC article.
TFG-1 function in protein secretion and oncogenesis.
Witte K, Schuh AL, Hegermann J, Sarkeshik A, Mayers JR, Schwarze K, Yates JR 3rd, Eimer S, Audhya A. Witte K, et al. Among authors: audhya a. Nat Cell Biol. 2011 May;13(5):550-8. doi: 10.1038/ncb2225. Epub 2011 Apr 10. Nat Cell Biol. 2011. PMID: 21478858 Free PMC article.
Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nürnberg G, Altmüller J, Saxena R, Chapman ER, Dent EW, Nürnberg P, Audhya A. Beetz C, et al. Among authors: audhya a. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6. doi: 10.1073/pnas.1217197110. Epub 2013 Mar 11. Proc Natl Acad Sci U S A. 2013. PMID: 23479643 Free PMC article. Clinical Trial.
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Hanna MG 4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. Hanna MG 4th, et al. Among authors: audhya a. J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287. Epub 2015 Nov 6. J Biol Chem. 2016. PMID: 26546679 Free PMC article.
TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.
Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A. Hanna MG 4th, et al. Among authors: audhya a. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7707-E7716. doi: 10.1073/pnas.1709120114. Epub 2017 Aug 29. Proc Natl Acad Sci U S A. 2017. PMID: 28851831 Free PMC article.
Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.
Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, Sheets MD, Butcher SE, Stagg SM, Audhya A. Slosarek EL, et al. Among authors: audhya a. Cell Rep. 2018 Aug 28;24(9):2248-2260. doi: 10.1016/j.celrep.2018.07.081. Cell Rep. 2018. PMID: 30157421 Free PMC article.
105 results