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Anti-inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate the domestication of alternative medicine.
Sudhakaran G, Prathap P, Guru A, Rajesh R, Sathish S, Madhavan T, Arasu MV, Al-Dhabi NA, Choi KC, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Among authors: rajesh r. Cell Biol Int. 2022 May;46(5):771-791. doi: 10.1002/cbin.11769. Epub 2022 Feb 3. Cell Biol Int. 2022. PMID: 35077598
Deacetylepoxyazadiradione Derived from Epoxyazadiradione of Neem (Azadirachta indica A. Juss) Fruits Mitigates LPS-Induced Oxidative Stress and Inflammation in Zebrafish Larvae.
Murugan R, Rajesh R, Guru A, Haridevamuthu B, Almutairi BO, Almutairi MH, Juliet A, Renganayagi S, Gopinath P, Arockiaraj J. Murugan R, et al. Among authors: rajesh r. Chem Biodivers. 2022 Sep;19(9):e202200041. doi: 10.1002/cbdv.202200041. Epub 2022 Aug 26. Chem Biodivers. 2022. PMID: 36026548
Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels.
Sudhakaran G, Rajesh R, Guru A, Haridevamuthu B, Murugan R, Bhuvanesh N, Wadaan MA, Mahboob S, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Among authors: rajesh r. Toxicol Appl Pharmacol. 2022 Nov 1;454:116229. doi: 10.1016/j.taap.2022.116229. Epub 2022 Sep 8. Toxicol Appl Pharmacol. 2022. PMID: 36089001
Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish.
Sudhakaran G, Rajesh R, Murugan R, Velayutham M, Guru A, Boopathi S, Muthupandian S, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Among authors: rajesh r. Phytother Res. 2023 Apr;37(4):1449-1461. doi: 10.1002/ptr.7685. Epub 2022 Nov 30. Phytother Res. 2023. PMID: 36450691
329 results