He R - Search Results

1

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.

He R, Wang J, Yu ZH, Moyers JS, Michael MD, Durham TB, Cramer JW, Qian Y, Lin A, Wu L, Noinaj N, Barrett DG, Zhang ZY. He R, et al. J Med Chem. 2022 Oct 27;65(20):13892-13909. doi: 10.1021/acs.jmedchem.2c01143. Epub 2022 Oct 5. J Med Chem. 2022. PMID: 36197449 Free PMC article.

2

Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.

He Y, Zeng LF, Yu ZH, He R, Liu S, Zhang ZY. He Y, et al. Among authors: he r. Bioorg Med Chem. 2012 Mar 15;20(6):1940-6. doi: 10.1016/j.bmc.2011.11.004. Epub 2011 Nov 9. Bioorg Med Chem. 2012. PMID: 22133902 Free PMC article.

3

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.

He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Zhang ZY. He R, et al. ACS Med Chem Lett. 2015 Nov 3;6(12):1231-5. doi: 10.1021/acsmedchemlett.5b00373. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713110 Free PMC article.

4

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.

He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY. He R, et al. J Med Chem. 2016 Oct 13;59(19):9094-9106. doi: 10.1021/acs.jmedchem.6b00993. Epub 2016 Oct 3. J Med Chem. 2016. PMID: 27676368 Free PMC article.

5

Protein tyrosine phosphatases as potential therapeutic targets.

He RJ, Yu ZH, Zhang RY, Zhang ZY. He RJ, et al. Acta Pharmacol Sin. 2014 Oct;35(10):1227-46. doi: 10.1038/aps.2014.80. Epub 2014 Sep 15. Acta Pharmacol Sin. 2014. PMID: 25220640 Free PMC article. Review.

6

Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.

He R, Yu Z, He Y, Zeng LF, Xu J, Wu L, Gunawan AM, Wang L, Jiang ZX, Zhang ZY. He R, et al. Among authors: he y. ChemMedChem. 2010 Dec 3;5(12):2051-6. doi: 10.1002/cmdc.201000348. ChemMedChem. 2010. PMID: 20957718 Free PMC article.

7

A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.

Zeng LF, Xu J, He Y, He R, Wu L, Gunawan AM, Zhang ZY. Zeng LF, et al. Among authors: he y, he r. ChemMedChem. 2013 Jun;8(6):904-8. doi: 10.1002/cmdc.201300115. Epub 2013 Apr 8. ChemMedChem. 2013. PMID: 23568546 Free PMC article.

8

Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.

He R, Bai Y, Yu ZH, Wu L, Gunawan AM, Zhang ZY. He R, et al. Medchemcomm. 2014 Oct;5(10):1496-1499. doi: 10.1039/C4MD00099D. Medchemcomm. 2014. PMID: 25505942 Free PMC article.

9

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Lane BS, Shim JS, Zeng LF, He Y, Chen L, Wells CD, Liu JO, Zhang ZY. He R, et al. Among authors: he y. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6. doi: 10.1021/acsmedchemlett.5b00118. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191366 Free PMC article.

10

Small molecule tools for functional interrogation of protein tyrosine phosphatases.

He R, Zeng LF, He Y, Zhang S, Zhang ZY. He R, et al. Among authors: he y. FEBS J. 2013 Jan;280(2):731-50. doi: 10.1111/j.1742-4658.2012.08718.x. Epub 2012 Aug 16. FEBS J. 2013. PMID: 22816879 Free PMC article. Review.

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