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Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure.
Mol Ther Nucleic Acids. 2023 Jul 19;33:599-616. doi: 10.1016/j.omtn.2023.07.020. eCollection 2023 Sep 12.
Mol Ther Nucleic Acids. 2023.
PMID: 37637207
Free PMC article.
Mouse IgG2a Isotype Therapeutic Antibodies Elicit Superior Tumor Growth Control Compared with mIgG1 or mIgE.
Vukovic N, Segués A, Huang S, Waterfall M, Sijts AJAM, Zaiss DM.
Vukovic N, et al. Among authors: segues a.
Cancer Res Commun. 2023 Jan 23;3(1):109-118. doi: 10.1158/2767-9764.CRC-22-0356. eCollection 2023 Jan.
Cancer Res Commun. 2023.
PMID: 36968226
Free PMC article.
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Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells.
Huang S, Segués A, Waterfall M, Wright D, Vayssiere C, van Duijnhoven SMJ, van Elsas A, Sijts AJAM, Zaiss DM.
Huang S, et al. Among authors: segues a.
Biomolecules. 2022 Sep 21;12(10):1331. doi: 10.3390/biom12101331.
Biomolecules. 2022.
PMID: 36291540
Free PMC article.
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Opportunities and challenges of bi-specific antibodies.
Segués A, Huang S, Sijts A, Berraondo P, Zaiss DM.
Segués A, et al.
Int Rev Cell Mol Biol. 2022;369:45-70. doi: 10.1016/bs.ircmb.2022.05.001. Epub 2022 May 30.
Int Rev Cell Mol Biol. 2022.
PMID: 35777864
Review.
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Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies.
Segués A, van Duijnhoven SMJ, Parade M, Driessen L, Vukovic N, Zaiss D, Sijts AJAM, Berraondo P, van Elsas A.
Segués A, et al.
J Immunol Methods. 2021 Dec;499:113173. doi: 10.1016/j.jim.2021.113173. Epub 2021 Oct 24.
J Immunol Methods. 2021.
PMID: 34699840
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Advances in mRNA-based drug discovery in cancer immunotherapy.
Di Trani CA, Fernandez-Sendin M, Cirella A, Segués A, Olivera I, Bolaños E, Melero I, Berraondo P.
Di Trani CA, et al. Among authors: segues a.
Expert Opin Drug Discov. 2022 Jan;17(1):41-53. doi: 10.1080/17460441.2021.1978972. Epub 2021 Sep 20.
Expert Opin Drug Discov. 2022.
PMID: 34496689
Review.
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A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing.
Huang S, Segués A, Hulsik DL, Zaiss DM, Sijts AJAM, van Duijnhoven SMJ, van Elsas A.
Huang S, et al. Among authors: segues a.
J Immunol Methods. 2020 Aug;483:112811. doi: 10.1016/j.jim.2020.112811. Epub 2020 Jun 19.
J Immunol Methods. 2020.
PMID: 32569598
Free article.
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