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Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.
Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST. Brito-Moreira J, et al. Among authors: gomes fca. J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283575 Free PMC article.
Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.
Frost PS, Barros-Aragão F, da Silva RT, Venancio A, Matias I, Lyra E Silva NM, Kincheski GC, Pimentel-Coelho PM, De Felice FG, Gomes FCA, Ferreira ST, Figueiredo CP, Clarke JR. Frost PS, et al. Among authors: gomes fca. Cell Death Dis. 2019 Apr 11;10(4):323. doi: 10.1038/s41419-019-1529-x. Cell Death Dis. 2019. PMID: 30975983 Free PMC article.
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.
Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. Fortuna JTS, et al. Among authors: gomes fca. Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29. Behav Brain Res. 2017. PMID: 28668282
Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Pitt J, et al. Among authors: gomes fca. Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9. Mol Biol Cell. 2017. PMID: 28963439 Free PMC article.
81 results