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Page 1
Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism.
Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, Aschenbrenner D, Kim-Schulze S, Lam YK, Berridge G, McGovern DPB, Kessler B, Fischer R, Klenerman P, Hester J, Issa F, Torres EA, Powrie F, Gochuico BR, Gahl WA, Cohen L, Uhlig HH. Cavounidis A, et al. Among authors: powrie f. Mucosal Immunol. 2022 Jun;15(6):1431-1446. doi: 10.1038/s41385-022-00572-1. Epub 2022 Oct 27. Mucosal Immunol. 2022. PMID: 36302964 Free PMC article.
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators; Keshav S, Travis SPL, Powrie F. West NR, et al. Among authors: powrie f. Nat Med. 2017 May;23(5):579-589. doi: 10.1038/nm.4307. Epub 2017 Apr 3. Nat Med. 2017. PMID: 28368383 Free PMC article.
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.
Alvarez-Martinez M, Cox LS, Pearson CF, Branchett WJ, Chakravarty P, Wu X, Slawinski H, Al-Dibouni A, Samelis VA, Gabryšová L, Priestnall SL, Suárez-Bonnet A, Mikolajczak A, Briscoe J, Powrie F, O'Garra A. Alvarez-Martinez M, et al. Among authors: powrie f. Nat Immunol. 2024 May;25(5):886-901. doi: 10.1038/s41590-024-01814-z. Epub 2024 Apr 12. Nat Immunol. 2024. PMID: 38609547 Free PMC article.
Immune microniches shape intestinal Treg function.
Gu Y, Bartolomé-Casado R, Xu C, Bertocchi A, Janney A, Heuberger C, Pearson CF, Teichmann SA, Thornton EE, Powrie F. Gu Y, et al. Among authors: powrie f. Nature. 2024 Apr;628(8009):854-862. doi: 10.1038/s41586-024-07251-0. Epub 2024 Apr 3. Nature. 2024. PMID: 38570678 Free PMC article.
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.
Thompson KN, Bonham KS, Ilott NE, Britton GJ, Colmenero P, Bullers SJ, McIver LJ, Ma S, Nguyen LH, Filer A, Brough I, Pearson C, Moussa C, Kumar V, Lam LH, Jackson MA, Pawluk A; Inflammatory Arthritis Microbiome Consortium (IAMC) investigators group; Kiriakidis S, Taylor PC, Wedderburn LR, Marsden B, Young SP, Littman DR, Faith JJ, Pratt AG, Bowness P, Raza K, Powrie F, Huttenhower C; IAMC. Thompson KN, et al. Among authors: powrie f. Sci Transl Med. 2023 Jul 26;15(706):eabn4722. doi: 10.1126/scitranslmed.abn4722. Epub 2023 Jul 26. Sci Transl Med. 2023. PMID: 37494472
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses.
Heuberger CE, Janney A, Ilott N, Bertocchi A, Pott S, Gu Y, Pohin M, Friedrich M, Mann EH, Pearson C, Powrie FM, Pott J, Thornton E, Maloy KJ. Heuberger CE, et al. Among authors: powrie fm. Mucosal Immunol. 2023 May 18:S1933-0219(23)00032-6. doi: 10.1016/j.mucimm.2023.05.001. Online ahead of print. Mucosal Immunol. 2023. PMID: 37209960 Free article.
Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Richter FC, Friedrich M, Kampschulte N, Piletic K, Alsaleh G, Zummach R, Hecker J, Pohin M, Ilott N, Guschina I, Wideman SK, Johnson E, Borsa M, Hahn P, Morriseau C, Hammock BD, Schipper HS, Edwards CM, Zechner R, Siegmund B, Weidinger C, Schebb NH, Powrie F, Simon AK. Richter FC, et al. Among authors: powrie f. EMBO J. 2023 Mar 15;42(6):e112202. doi: 10.15252/embj.2022112202. Epub 2023 Feb 16. EMBO J. 2023. PMID: 36795015 Free PMC article.
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice.
Hackstein CP, Costigan D, Drexhage L, Pearson C, Bullers S, Ilott N, Akther HD, Gu Y, FitzPatrick MEB, Harrison OJ, Garner LC, Mann EH, Pandey S, Friedrich M, Provine NM, Uhlig HH, Marchi E, Powrie F, Klenerman P, Thornton EE. Hackstein CP, et al. Among authors: powrie f. Nat Commun. 2022 Dec 3;13(1):7472. doi: 10.1038/s41467-022-35126-3. Nat Commun. 2022. PMID: 36463279 Free PMC article.
A viral cocktail calms gut inflammation.
Bertocchi A, Powrie F. Bertocchi A, et al. Among authors: powrie f. Nature. 2022 Dec;612(7939):220-221. doi: 10.1038/d41586-022-03703-7. Nature. 2022. PMID: 36447035 No abstract available.
204 results