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A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex.
Michon M, Müller-Schiffmann A, Lingappa AF, Yu SF, Du L, Deiter F, Broce S, Mallesh S, Crabtree J, Lingappa UF, Macieik A, Müller L, Ostermann PN, Andrée M, Adams O, Schaal H, Hogan RJ, Tripp RA, Appaiah U, Anand SK, Campi TW, Ford MJ, Reed JC, Lin J, Akintunde O, Copeland K, Nichols C, Petrouski E, Moreira AR, Jiang IT, DeYarman N, Brown I, Lau S, Segal I, Goldsmith D, Hong S, Asundi V, Briggs EM, Phyo NS, Froehlich M, Onisko B, Matlack K, Dey D, Lingappa JR, Prasad DM, Kitaygorodskyy A, Solas D, Boushey H, Greenland J, Pillai S, Lo MK, Montgomery JM, Spiropoulou CF, Korth C, Selvarajah S, Paulvannan K, Lingappa VR. Michon M, et al. Among authors: brown i. Open Biol. 2024 Jun;14(6):230363. doi: 10.1098/rsob.230363. Epub 2024 Jun 19. Open Biol. 2024. PMID: 38889796 Free article.
It pays to follow the leader: Metabolic cost of flight is lower for trailing birds in small groups.
Friman SI, Elowe CR, Hao S, Mendez L, Ayala R, Brown I, Hagood C, Hedlund Y, Jackson D, Killi J, Orfanides G, Ozcan E, Ramirez J, Gerson AR, Breuer KS, Hedrick TL. Friman SI, et al. Among authors: brown i. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2319971121. doi: 10.1073/pnas.2319971121. Epub 2024 Jun 17. Proc Natl Acad Sci U S A. 2024. PMID: 38885375
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PAS, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes Dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M. Venkateswaran N, et al. Among authors: brown in. Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3. Nat Commun. 2024. PMID: 38769298 Free PMC article.
1,584 results