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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity.
Zhang Q, Liu S, Zhang CS, Wu Q, Yu X, Zhou R, Meng F, Wang A, Zhang F, Chen S, Wang X, Li L, Huang J, Huang YW, Zou J, Qin J, Liang T, Feng XH, Lin SC, Xu P. Zhang Q, et al. Among authors: chen s. Mol Cell. 2022 Dec 1;82(23):4519-4536.e7. doi: 10.1016/j.molcel.2022.10.026. Epub 2022 Nov 15. Mol Cell. 2022. PMID: 36384137 Free article.
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity.
Meng F, Yu Z, Zhang D, Chen S, Guan H, Zhou R, Wu Q, Zhang Q, Liu S, Venkat Ramani MK, Yang B, Ba XQ, Zhang J, Huang J, Bai X, Qin J, Feng XH, Ouyang S, Zhang YJ, Liang T, Xu P. Meng F, et al. Among authors: chen s. Mol Cell. 2021 Oct 21;81(20):4147-4164.e7. doi: 10.1016/j.molcel.2021.07.040. Epub 2021 Aug 27. Mol Cell. 2021. PMID: 34453890 Free article.
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.
Wang A, Chen C, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu Y, Chen S, Zhang Q, Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X, Shen C, Xu P. Wang A, et al. Among authors: chen c, chen s. Nat Cell Biol. 2024 Feb;26(2):219-234. doi: 10.1038/s41556-023-01339-x. Epub 2024 Jan 22. Nat Cell Biol. 2024. PMID: 38253667
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y. Xue C, et al. Among authors: chen l, chen s, chen h, chen y. Cell Rep. 2024 Sep 24;43(9):114691. doi: 10.1016/j.celrep.2024.114691. Epub 2024 Sep 3. Cell Rep. 2024. PMID: 39235944 Free article.
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