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Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel.
Nat Commun. 2024 Jan 2;15(1):25. doi: 10.1038/s41467-023-44366-w.
Nat Commun. 2024.
PMID: 38167383
Free PMC article.
Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Petroff JT 2nd, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL.
Petroff JT 2nd, et al. Among authors: dietzen nm.
Nat Commun. 2022 Nov 17;13(1):7017. doi: 10.1038/s41467-022-34813-5.
Nat Commun. 2022.
PMID: 36385237
Free PMC article.
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Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites.
Dietzen NM, Arcario MJ, Chen LJ, Petroff JT 2nd, Moreland KT, Krishnan K, Brannigan G, Covey DF, Cheng WW.
Dietzen NM, et al.
Elife. 2022 Jan 4;11:e74306. doi: 10.7554/eLife.74306.
Elife. 2022.
PMID: 34982031
Free PMC article.
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