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Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats.
Brems BM, Sullivan EE, Connolly JG, Zhang J, Chang A, Ortiz R, Cantwell L, Kulkarni P, Thakur GA, Ferris CF. Brems BM, et al. Among authors: thakur ga. Front Neurosci. 2023 Jun 23;17:1196786. doi: 10.3389/fnins.2023.1196786. eCollection 2023. Front Neurosci. 2023. PMID: 37424993 Free PMC article.
GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation.
Gauthier AG, Lin M, Zefi S, Kulkarni A, Thakur GA, Ashby CR Jr, Mantell LL. Gauthier AG, et al. Among authors: thakur ga. Redox Biol. 2023 Apr;60:102614. doi: 10.1016/j.redox.2023.102614. Epub 2023 Jan 20. Redox Biol. 2023. PMID: 36717349 Free PMC article.
Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation.
Andleeb H, Papke RL, Stokes C, Richter K, Herz SM, Chiang K, Kanumuri SRR, Sharma A, Damaj MI, Grau V, Horenstein NA, Thakur GA. Andleeb H, et al. Among authors: thakur ga. J Med Chem. 2024 Jun 13;67(11):8642-8666. doi: 10.1021/acs.jmedchem.3c02429. Epub 2024 May 15. J Med Chem. 2024. PMID: 38748608 Free PMC article.
129 results