Cavalcante WLG - Search Results

1

Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib.

Salvador GHM, Pinto ÊKR, Ortolani PL, Fortes-Dias CL, Cavalcante WLG, Soares AM, Lomonte B, Lewin MR, Fontes MRM. Salvador GHM, et al. Among authors: cavalcante wlg. Biochimie. 2023 Apr;207:1-10. doi: 10.1016/j.biochi.2022.11.006. Epub 2022 Nov 17. Biochimie. 2023. PMID: 36403756

2

Structural and phylogenetic studies with MjTX-I reveal a multi-oligomeric toxin--a novel feature in Lys49-PLA2s protein class.

Salvador GH, Fernandes CA, Magro AJ, Marchi-Salvador DP, Cavalcante WL, Fernandez RM, Gallacci M, Soares AM, Oliveira CL, Fontes MR. Salvador GH, et al. PLoS One. 2013;8(4):e60610. doi: 10.1371/journal.pone.0060610. Epub 2013 Apr 3. PLoS One. 2013. PMID: 23573271 Free PMC article.

3

Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A₂-like.

Salvador GH, Cavalcante WL, Dos Santos JI, Gallacci M, Soares AM, Fontes MR. Salvador GH, et al. Toxicon. 2013 Sep;72:52-63. doi: 10.1016/j.toxicon.2013.06.013. Epub 2013 Jun 25. Toxicon. 2013. PMID: 23810946 Free article.

4

Biochemical, functional, structural and phylogenetic studies on Intercro, a new isoform phospholipase A2 from Crotalus durissus terrificus snake venom.

Vieira LF, Magro AJ, Fernandes CA, de Souza BM, Cavalcante WL, Palma MS, Rosa JC, Fuly AL, Fontes MR, Gallacci M, Butzke DS, Calderon LA, Stábeli RG, Giglio JR, Soares AM. Vieira LF, et al. Biochimie. 2013 Dec;95(12):2365-75. doi: 10.1016/j.biochi.2013.08.028. Epub 2013 Sep 11. Biochimie. 2013. PMID: 24035779 Free article.

5

Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism.

Salvador GHM, Dreyer TR, Gomes AAS, Cavalcante WLG, Dos Santos JI, Gandin CA, de Oliveira Neto M, Gallacci M, Fontes MRM. Salvador GHM, et al. Among authors: cavalcante wlg. Sci Rep. 2018 Jul 9;8(1):10317. doi: 10.1038/s41598-018-28584-7. Sci Rep. 2018. PMID: 29985425 Free PMC article.

6

Structural basis of phospholipase A₂-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins.

Cardoso FF, Borges RJ, Dreyer TR, Salvador GHM, Cavalcante WLG, Pai MD, Gallacci M, Fontes MRM. Cardoso FF, et al. Among authors: cavalcante wlg. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2728-2737. doi: 10.1016/j.bbagen.2018.08.002. Epub 2018 Aug 4. Biochim Biophys Acta Gen Subj. 2018. PMID: 30251662

7

Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A₂-like proteins using functional, structural and bioinformatics approaches.

Salvador GHM, Cardoso FF, Gomes AA, Cavalcante WLG, Gallacci M, Fontes MRM. Salvador GHM, et al. Among authors: cavalcante wlg. Sci Rep. 2019 Jan 24;9(1):510. doi: 10.1038/s41598-018-36839-6. Sci Rep. 2019. PMID: 30679550 Free PMC article.

8

Neutralization of a bothropic PLA₂-like protein by caftaric acid, a novel potent inhibitor of ophidian myotoxicity.

Cardoso FF, Gomes AAS, Dreyer TR, Cavalcante WLG, Dal Pai M, Gallacci M, Fontes MRM. Cardoso FF, et al. Among authors: cavalcante wlg. Biochimie. 2020 Mar;170:163-172. doi: 10.1016/j.biochi.2020.01.010. Epub 2020 Jan 22. Biochimie. 2020. PMID: 31978419

9

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin.

Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR. Salvador GH, et al. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi: 10.1107/S1399004715014443. Epub 2015 Sep 26. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26457430

10

Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism.

Fernandes CA, Pazin WM, Dreyer TR, Bicev RN, Cavalcante WL, Fortes-Dias CL, Ito AS, Oliveira CL, Fernandez RM, Fontes MR. Fernandes CA, et al. Sci Rep. 2017 Mar 3;7:43885. doi: 10.1038/srep43885. Sci Rep. 2017. PMID: 28256632 Free PMC article.

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