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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Huang WS, Li F, Gong Y, Zhang Y, Youngsaye W, Xu Y, Zhu X, Greenfield MT, Kohlmann A, Taslimi PM, Toms A, Zech SG, Zhou T, Das B, Jang HG, Tugnait M, Ye YE, Gonzalvez F, Baker TE, Nadworny S, Ning Y, Wardwell SD, Zhang S, Gould AE, Hu Y, Lane W, Skene RJ, Zou H, Clackson T, Narasimhan NI, Rivera VM, Dalgarno DC, Shakespeare WC. Huang WS, et al. Among authors: youngsaye w. Bioorg Med Chem Lett. 2023 Jan 15;80:129084. doi: 10.1016/j.bmcl.2022.129084. Epub 2022 Nov 21. Bioorg Med Chem Lett. 2023. PMID: 36423823 Free article.
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.
Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Youngsaye W, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5502-5. doi: 10.1016/j.bmcl.2011.06.105. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21802942 Free PMC article.
Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Dockendorff C, Faloon PW, Germain A, Yu M, Youngsaye W, Nag PP, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Dockendorff C, et al. Among authors: youngsaye w. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2594-8. doi: 10.1016/j.bmcl.2015.03.074. Epub 2015 Apr 11. Bioorg Med Chem Lett. 2015. PMID: 25958245 Free PMC article.
Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Lewis TA, de Waal L, Wu X, Youngsaye W, Wengner A, Kopitz C, Lange M, Gradl S, Ellermann M, Lienau P, Schreiber SL, Greulich H, Meyerson M. Lewis TA, et al. Among authors: youngsaye w. ACS Med Chem Lett. 2019 Oct 18;10(11):1537-1542. doi: 10.1021/acsmedchemlett.9b00360. eCollection 2019 Nov 14. ACS Med Chem Lett. 2019. PMID: 31749907 Free PMC article.
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.
Dockendorff C, Nagiec MM, Weïwer M, Buhrlage S, Ting A, Nag PP, Germain A, Kim HJ, Youngsaye W, Scherer C, Bennion M, Xue L, Stanton BZ, Lewis TA, Macpherson L, Palmer M, Foley MA, Perez JR, Schreiber SL. Dockendorff C, et al. Among authors: youngsaye w. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813. doi: 10.1021/ml300172p. Epub 2012 Aug 30. ACS Med Chem Lett. 2012. PMID: 23074541 Free PMC article.
Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport.
Dockendorff C, Faloon PW, Yu M, Youngsaye W, Penman M, Nieland TJ, Nag PP, Lewis TA, Pu J, Bennion M, Negri J, Paterson C, Lam G, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Dockendorff C, et al. Among authors: youngsaye w. ACS Med Chem Lett. 2015 Feb 2;6(4):375-380. doi: 10.1021/ml500154q. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 26478787 Free PMC article.
Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.
McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. McLellan CA, et al. Among authors: youngsaye w. Nat Chem Biol. 2018 Feb;14(2):135-141. doi: 10.1038/nchembio.2534. Epub 2017 Dec 11. Nat Chem Biol. 2018. PMID: 29227471 Free PMC article.
A Candidate Cell-Selective Anticancer Agent.
Lewis TA, de Waal L, Youngsaye W, Gechijian L, Hickey M, Faloon P, Mikse O, Dandapani S, Wong K, Tolliday N, Munoz B, Palmer M, Greulich H, Meyerson ML, Schreiber SL. Lewis TA, et al. Among authors: youngsaye w. 2013 Dec 12 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2013 Dec 12 [updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 25506970 Free Books & Documents. Review.
23 results