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NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: hutchings km. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.
5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.
Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD. Kahl DJ, et al. Among authors: hutchings km. J Med Chem. 2019 May 9;62(9):4350-4369. doi: 10.1021/acs.jmedchem.8b01772. Epub 2019 Apr 18. J Med Chem. 2019. PMID: 30951312 Free PMC article.
Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.
Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Hutchings KM, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. doi: 10.1016/j.bmcl.2017.02.070. Epub 2017 Mar 10. Bioorg Med Chem Lett. 2017. PMID: 28285914 Free PMC article.
Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.
Hutchings KM, Tran TP, Ellsworth EL, Watson BM, Sanchez JP, Showalter HD, Stier MA, Shapiro M, Themis Joannides E, Huband M, Nguyen DQ, Maiti S, Li T, Tailor J, Thomas G, Ha C, Singh R. Hutchings KM, et al. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5087-90. doi: 10.1016/j.bmcl.2008.07.117. Epub 2008 Aug 3. Bioorg Med Chem Lett. 2008. PMID: 18752951