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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3.
Commun Chem. 2024.
PMID: 38378740
Free PMC article.
Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors.
Hoyt KW, Urul DA, Ogboo BC, Wittlinger F, Laufer SA, Schaefer EM, May EW, Heppner DE.
Hoyt KW, et al. Among authors: urul da.
J Med Chem. 2024 Jan 11;67(1):2-16. doi: 10.1021/acs.jmedchem.3c01502. Epub 2023 Dec 22.
J Med Chem. 2024.
PMID: 38134304
Review.
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Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Heppner DE, Wittlinger F, Beyett TS, Shaurova T, Urul DA, Buckley B, Pham CD, Schaeffner IK, Yang B, Ogboo BC, May EW, Schaefer EM, Eck MJ, Laufer SA, Hershberger PA.
Heppner DE, et al. Among authors: urul da.
ACS Med Chem Lett. 2022 Nov 10;13(12):1856-1863. doi: 10.1021/acsmedchemlett.2c00213. eCollection 2022 Dec 8.
ACS Med Chem Lett. 2022.
PMID: 36518696
Free PMC article.
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REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins.
Long MJC, Urul DA, Aye Y.
Long MJC, et al. Among authors: urul da.
Methods Enzymol. 2020;633:203-230. doi: 10.1016/bs.mie.2019.02.039. Epub 2019 Mar 14.
Methods Enzymol. 2020.
PMID: 32046846
Free PMC article.
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Single-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegans.
Van Hall-Beauvais A, Zhao Y, Urul DA, Long MJC, Aye Y.
Van Hall-Beauvais A, et al. Among authors: urul da.
Curr Protoc Chem Biol. 2018 Sep;10(3):e43. doi: 10.1002/cpch.43. Epub 2018 Aug 7.
Curr Protoc Chem Biol. 2018.
PMID: 30085412
Free PMC article.
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Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor.
Surya SL, Long MJC, Urul DA, Zhao Y, Mercer EJ, EIsaid IM, Evans T, Aye Y.
Surya SL, et al. Among authors: urul da.
ACS Chem Biol. 2018 Jul 20;13(7):1824-1831. doi: 10.1021/acschembio.7b00925. Epub 2018 Feb 8.
ACS Chem Biol. 2018.
PMID: 29397684
Free PMC article.
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Precision Electrophile Tagging in Caenorhabditis elegans.
Long MJC, Urul DA, Chawla S, Lin HY, Zhao Y, Haegele JA, Wang Y, Aye Y.
Long MJC, et al. Among authors: urul da.
Biochemistry. 2018 Jan 16;57(2):216-220. doi: 10.1021/acs.biochem.7b00642. Epub 2017 Sep 12.
Biochemistry. 2018.
PMID: 28857552
Free PMC article.
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