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Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Di Bello E, Sian V, Bontempi G, Zwergel C, Fioravanti R, Noce B, Castiello C, Tomassi S, Corinti D, Passeri D, Pellicciari R, Mercurio C, Varasi M, Altucci L, Tripodi M, Strippoli R, Nebbioso A, Valente S, Mai A. Di Bello E, et al. Among authors: strippoli r. Eur J Med Chem. 2023 Feb 5;247:115022. doi: 10.1016/j.ejmech.2022.115022. Epub 2022 Dec 15. Eur J Med Chem. 2023. PMID: 36549114
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S. Stazi G, et al. Among authors: strippoli r. Eur J Med Chem. 2019 Feb 1;163:722-735. doi: 10.1016/j.ejmech.2018.11.050. Epub 2018 Nov 28. Eur J Med Chem. 2019. PMID: 30576903
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells.
Zwergel C, Schnekenburger M, Sarno F, Battistelli C, Manara MC, Stazi G, Mazzone R, Fioravanti R, Gros C, Ausseil F, Florean C, Nebbioso A, Strippoli R, Ushijima T, Scotlandi K, Tripodi M, Arimondo PB, Altucci L, Diederich M, Mai A, Valente S. Zwergel C, et al. Among authors: strippoli r. Clin Epigenetics. 2019 May 6;11(1):68. doi: 10.1186/s13148-019-0663-8. Clin Epigenetics. 2019. PMID: 31060628 Free PMC article.
Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
Zwergel C, Fioravanti R, Stazi G, Sarno F, Battistelli C, Romanelli A, Nebbioso A, Mendes E, Paulo A, Strippoli R, Tripodi M, Pechalrieu D, Arimondo PB, De Luca T, Del Bufalo D, Trisciuoglio D, Altucci L, Valente S, Mai A. Zwergel C, et al. Among authors: strippoli r. Cancers (Basel). 2020 Feb 14;12(2):447. doi: 10.3390/cancers12020447. Cancers (Basel). 2020. PMID: 32075099 Free PMC article.
Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.
Romanelli A, Stazi G, Fioravanti R, Zwergel C, Di Bello E, Pomella S, Perrone C, Battistelli C, Strippoli R, Tripodi M, Del Bufalo D, Rota R, Trisciuoglio D, Mai A, Valente S. Romanelli A, et al. Among authors: strippoli r. ACS Med Chem Lett. 2020 Mar 19;11(5):977-983. doi: 10.1021/acsmedchemlett.0c00014. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435414 Free PMC article.
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