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Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.
Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. Shahpasand-Kroner H, et al. Pharmacol Rev. 2023 Mar;75(2):263-308. doi: 10.1124/pharmrev.122.000654. Epub 2022 Dec 22. Pharmacol Rev. 2023. PMID: 36549866 Free PMC article. Review.
The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties.
Olari LR, Bauer R, Gil Miró M, Vogel V, Cortez Rayas L, Groß R, Gilg A, Klevesath R, Rodríguez Alfonso AA, Kaygisiz K, Rupp U, Pant P, Mieres-Pérez J, Steppe L, Schäffer R, Rauch-Wirth L, Conzelmann C, Müller JA, Zech F, Gerbl F, Bleher J, Preising N, Ständker L, Wiese S, Thal DR, Haupt C, Jonker HRA, Wagner M, Sanchez-Garcia E, Weil T, Stenger S, Fändrich M, von Einem J, Read C, Walther P, Kirchhoff F, Spellerberg B, Münch J. Olari LR, et al. Cell Mol Life Sci. 2023 May 17;80(6):151. doi: 10.1007/s00018-023-04795-8. Cell Mol Life Sci. 2023. PMID: 37198527 Free PMC article.
A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. Ortega-Molina A, et al. Among authors: sanchez garcia e. Nat Aging. 2024 Jun 7. doi: 10.1038/s43587-024-00635-x. Online ahead of print. Nat Aging. 2024. PMID: 38849535
TopBP1 utilises a bipartite GINS binding mode to support genome replication.
Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D. Day M, et al. Among authors: sanchez garcia e. Nat Commun. 2024 Feb 27;15(1):1797. doi: 10.1038/s41467-024-45946-0. Nat Commun. 2024. PMID: 38413589 Free PMC article.
Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability.
Harms M, Fabech Hansson R, Gilg A, Almeida-Hernández Y, Löffler J, Rodríguez-Alfonso A, Habib MMW, Albers D, Ahmed NS, Abadi AH, Winter G, Rasche V, Beer AJ, Weidinger G, Preising N, Ständker L, Wiese S, Sanchez-Garcia E, Zelikin AN, Münch J. Harms M, et al. Among authors: sanchez garcia e. J Med Chem. 2023 Nov 23;66(22):15189-15204. doi: 10.1021/acs.jmedchem.3c01128. Epub 2023 Nov 8. J Med Chem. 2023. PMID: 37940118 Free PMC article.
167 results