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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. Saul D, et al. Among authors: zhang x. Nat Commun. 2022 Aug 16;13(1):4827. doi: 10.1038/s41467-022-32552-1. Nat Commun. 2022. PMID: 35974106 Free PMC article.
The senescence-associated secretome as an indicator of age and medical risk.
Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK. Schafer MJ, et al. Among authors: zhang x. JCI Insight. 2020 Jun 18;5(12):e133668. doi: 10.1172/jci.insight.133668. JCI Insight. 2020. PMID: 32554926 Free PMC article.
Long noncoding RNAs in hematopoiesis.
Zhang X, Hu W. Zhang X, et al. F1000Res. 2016 Jul 20;5:F1000 Faculty Rev-1771. doi: 10.12688/f1000research.8349.1. eCollection 2016. F1000Res. 2016. PMID: 27508063 Free PMC article. Review.
Exercise reduces circulating biomarkers of cellular senescence in humans.
Englund DA, Sakamoto AE, Fritsche CM, Heeren AA, Zhang X, Kotajarvi BR, Lecy DR, Yousefzadeh MJ, Schafer MJ, White TA, Atkinson EJ, LeBrasseur NK. Englund DA, et al. Among authors: zhang x. Aging Cell. 2021 Jul;20(7):e13415. doi: 10.1111/acel.13415. Epub 2021 Jun 8. Aging Cell. 2021. PMID: 34101960 Free PMC article.
Exercise Counters the Age-Related Accumulation of Senescent Cells.
Zhang X, Englund DA, Aversa Z, Jachim SK, White TA, LeBrasseur NK. Zhang X, et al. Exerc Sport Sci Rev. 2022 Oct 1;50(4):213-221. doi: 10.1249/JES.0000000000000302. Epub 2022 Jul 1. Exerc Sport Sci Rev. 2022. PMID: 35776782 Free PMC article.
Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance.
Zhang X, Pearsall VM, Carver CM, Atkinson EJ, Clarkson BDS, Grund EM, Baez-Faria M, Pavelko KD, Kachergus JM, White TA, Johnson RK, Malo CS, Gonzalez-Suarez AM, Ayasoufi K, Johnson KO, Tritz ZP, Fain CE, Khadka RH, Ogrodnik M, Jurk D, Zhu Y, Tchkonia T, Revzin A, Kirkland JL, Johnson AJ, Howe CL, Thompson EA, LeBrasseur NK, Schafer MJ. Zhang X, et al. Nat Commun. 2022 Sep 27;13(1):5671. doi: 10.1038/s41467-022-33226-8. Nat Commun. 2022. PMID: 36167854 Free PMC article.
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