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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.
Vital T, Wali A, Butler KV, Xiong Y, Foster JP 2nd, Marcel SS, McFadden AW, Nguyen VU, Bailey BM, Lamb KN, James LI, Frye SV, Mosely AL, Jin J, Pattenden SG, Davis IJ. Vital T, et al. Among authors: xiong y. Front Oncol. 2023 Jan 30;13:1099550. doi: 10.3389/fonc.2023.1099550. eCollection 2023. Front Oncol. 2023. PMID: 36793594 Free PMC article.
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Liu F, et al. Among authors: xiong y. J Med Chem. 2013 Nov 14;56(21):8931-42. doi: 10.1021/jm401480r. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24102134 Free PMC article.
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.
Wagner T, Greschik H, Burgahn T, Schmidtkunz K, Schott AK, McMillan J, Baranauskienė L, Xiong Y, Fedorov O, Jin J, Oppermann U, Matulis D, Schüle R, Jung M. Wagner T, et al. Among authors: xiong y. Nucleic Acids Res. 2016 May 19;44(9):e88. doi: 10.1093/nar/gkw089. Epub 2016 Feb 17. Nucleic Acids Res. 2016. PMID: 26893353 Free PMC article.
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Park KS, Xiong Y, Yim H, Velez J, Babault N, Kumar P, Liu J, Jin J. Park KS, et al. Among authors: xiong y. J Med Chem. 2022 Aug 11;65(15):10506-10522. doi: 10.1021/acs.jmedchem.2c00652. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763668 Free PMC article.
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