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A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Chen Y, Lear TB, Evankovich JW, Larsen MB, Lin B, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Lockwood KC, Liu J, Myerburg MM, McDyer JF, Liu Y, Finkel T, Chen BB. Chen Y, et al. Among authors: lear tb. Res Sq [Preprint]. 2020 Aug 14:rs.3.rs-48659. doi: 10.21203/rs.3.rs-48659/v1. Res Sq. 2020. Update in: Nat Commun. 2021 Jun 23;12(1):3907. doi: 10.1038/s41467-021-24156-y. PMID: 32818215 Free PMC article. Updated. Preprint.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK. Liu Y, et al. Among authors: lear tb. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. Nat Chem Biol. 2021. PMID: 33495648 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33506775
[No title available]
[No authors listed] [No authors listed] PMID: 35560756
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.
Lockwood KC, Lear TB, Rajbhandari S, McKelvey AC, Dunn SR, Boudreau ÁN, Liu Y, Chen BB. Lockwood KC, et al. Among authors: lear tb. FEBS J. 2023 Aug;290(15):3802-3811. doi: 10.1111/febs.16780. Epub 2023 Apr 7. FEBS J. 2023. PMID: 36938956 Free PMC article.
31 results