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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
Randolph JT, O'Connor MJ, Han F, Hutchins CW, Siu YA, Cho M, Zheng Y, Hickson JA, Markley JL, Manaves V, Algire M, Baker KA, Chapman AM, Gopalakrishnan SM, Panchal SC, Foster-Duke K, Stolarik DF, Kempf-Grote A, Dammeier D, Fossey S, Sun Q, Sun C, Shen Y, Dart MJ, Kati WM, Lai A, Firestone AJ, Kort ME. Randolph JT, et al. Among authors: han f. J Med Chem. 2023 Mar 23;66(6):3852-3865. doi: 10.1021/acs.jmedchem.2c01415. Epub 2023 Mar 6. J Med Chem. 2023. PMID: 36877935
Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis.
Han F, Dellacecca ER, Barse LW, Cosgrove C, Henning SW, Ankney CM, Jaishankar D, Yemelyanov A, Krymskaya VP, Dilling DF, Le Poole IC. Han F, et al. Am J Respir Cell Mol Biol. 2020 Jun;62(6):793-804. doi: 10.1165/rcmb.2019-0117OC. Am J Respir Cell Mol Biol. 2020. PMID: 32078336 Free PMC article.
Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice.
Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca CC, Han F, Barse L, Henning SW, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack SR, Ramesh P, Jaishankar D, Lo AS, Moss J, Picken MM, Darling TN, Scholtens DM, Dilling DF, Junghans RP, Le Poole IC. Thomas A, et al. Among authors: han f. JCI Insight. 2021 Nov 22;6(22):e152014. doi: 10.1172/jci.insight.152014. JCI Insight. 2021. PMID: 34806651 Free PMC article.
4,942 results