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Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer.
Heylen E, Verstraete P, Van Aerschot L, Geeraerts SL, Venken T, Timcheva K, Nittner D, Verbeeck J, Royaert J, Gijbels M, Uyttebroeck A, Segers H, Lambrechts D, Cools J, De Keersmaecker K, Kampen KR. Heylen E, et al. Among authors: cools j. Br J Cancer. 2023 May;128(10):1862-1878. doi: 10.1038/s41416-023-02216-y. Epub 2023 Mar 17. Br J Cancer. 2023. PMID: 36932191 Free PMC article.
In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J. De Keersmaecker K, et al. Among authors: cools j. Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5. Haematologica. 2008. PMID: 18322257 Free article.
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J. Kleppe M, et al. Among authors: cools j. Nat Genet. 2010 Jun;42(6):530-5. doi: 10.1038/ng.587. Epub 2010 May 16. Nat Genet. 2010. PMID: 20473312 Free PMC article.
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. Schmidt T, et al. Among authors: cools j. Cancer Cell. 2011 Jun 14;19(6):740-53. doi: 10.1016/j.ccr.2011.05.007. Cancer Cell. 2011. PMID: 21665148 Free article.
226 results