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The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.
Obergasteiger J, Castonguay AM, Pizzi S, Magnabosco S, Frapporti G, Lobbestael E, Baekelandt V, Hicks AA, Pramstaller PP, Gravel C, Corti C, Lévesque M, Volta M. Obergasteiger J, et al. Among authors: volta m. NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2. NPJ Parkinsons Dis. 2023. PMID: 36973269 Free PMC article.
CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.
Obergasteiger J, Überbacher C, Pramstaller PP, Hicks AA, Corti C, Volta M. Obergasteiger J, et al. Among authors: volta m. Biochem Biophys Res Commun. 2017 Aug 26;490(3):876-881. doi: 10.1016/j.bbrc.2017.06.134. Epub 2017 Jun 21. Biochem Biophys Res Commun. 2017. PMID: 28647363
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.
Überbacher C, Obergasteiger J, Volta M, Venezia S, Müller S, Pesce I, Pizzi S, Lamonaca G, Picard A, Cattelan G, Malpeli G, Zoli M, Beccano-Kelly D, Flynn R, Wade-Martins R, Pramstaller PP, Hicks AA, Cowley SA, Corti C. Überbacher C, et al. Among authors: volta m. Stem Cell Res. 2019 Dec;41:101656. doi: 10.1016/j.scr.2019.101656. Epub 2019 Nov 9. Stem Cell Res. 2019. PMID: 31733438 Free PMC article.
Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.
Obergasteiger J, Frapporti G, Lamonaca G, Pizzi S, Picard A, Lavdas AA, Pischedda F, Piccoli G, Hilfiker S, Lobbestael E, Baekelandt V, Hicks AA, Corti C, Pramstaller PP, Volta M. Obergasteiger J, et al. Among authors: volta m. Cell Death Discov. 2020 Jun 8;6:45. doi: 10.1038/s41420-020-0279-y. eCollection 2020. Cell Death Discov. 2020. PMID: 32550012 Free PMC article.
Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging.
Walker MD, Volta M, Cataldi S, Dinelle K, Beccano-Kelly D, Munsie L, Kornelsen R, Mah C, Chou P, Co K, Khinda J, Mroczek M, Bergeron S, Yu K, Cao LP, Funk N, Ott T, Galter D, Riess O, Biskup S, Milnerwood AJ, Stoessl AJ, Farrer MJ, Sossi V. Walker MD, et al. Among authors: volta m. J Parkinsons Dis. 2014;4(3):483-98. doi: 10.3233/JPD-140344. J Parkinsons Dis. 2014. PMID: 25000966
67 results