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Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik IA, Yung PYK, Navarro C, Bolondi A, Kumar AS, Anania C, Brändl B, Meierhofer D, Lupiáñez DG, Müller FJ, Aktas T, Elsässer SJ, Kretzmer H, Smith ZD, Meissner A. Weigert R, et al. Among authors: hetzel s. Nat Cell Biol. 2023 Apr;25(4):579-591. doi: 10.1038/s41556-023-01114-y. Epub 2023 Apr 6. Nat Cell Biol. 2023. PMID: 37024684 Free PMC article.
Nanopype: a modular and scalable nanopore data processing pipeline.
Giesselmann P, Hetzel S, Müller FJ, Meissner A, Kretzmer H. Giesselmann P, et al. Among authors: hetzel s. Bioinformatics. 2019 Nov 1;35(21):4536. doi: 10.1093/bioinformatics/btz547. Bioinformatics. 2019. PMID: 31386105 No abstract available.
Epigenetic regulator function through mouse gastrulation.
Grosswendt S, Kretzmer H, Smith ZD, Kumar AS, Hetzel S, Wittler L, Klages S, Timmermann B, Mukherji S, Meissner A. Grosswendt S, et al. Among authors: hetzel s. Nature. 2020 Aug;584(7819):102-108. doi: 10.1038/s41586-020-2552-x. Epub 2020 Jul 29. Nature. 2020. PMID: 32728215 Free PMC article.
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Rossmann MP, et al. Among authors: hetzel s. Science. 2021 May 14;372(6543):716-721. doi: 10.1126/science.aaz2740. Science. 2021. PMID: 33986176 Free PMC article.
Acute lymphoblastic leukemia displays a distinct highly methylated genome.
Hetzel S, Mattei AL, Kretzmer H, Qu C, Chen X, Fan Y, Wu G, Roberts KG, Luger S, Litzow M, Rowe J, Paietta E, Stock W, Mardis ER, Wilson RK, Downing JR, Mullighan CG, Meissner A. Hetzel S, et al. Nat Cancer. 2022 Jun;3(6):768-782. doi: 10.1038/s43018-022-00370-5. Epub 2022 May 19. Nat Cancer. 2022. PMID: 35590059 Free PMC article.
Hijacking of transcriptional condensates by endogenous retroviruses.
Asimi V, Sampath Kumar A, Niskanen H, Riemenschneider C, Hetzel S, Naderi J, Fasching N, Popitsch N, Du M, Kretzmer H, Smith ZD, Weigert R, Walther M, Mamde S, Meierhofer D, Wittler L, Buschow R, Timmermann B, Cisse II, Ameres SL, Meissner A, Hnisz D. Asimi V, et al. Among authors: hetzel s. Nat Genet. 2022 Aug;54(8):1238-1247. doi: 10.1038/s41588-022-01132-w. Epub 2022 Jul 21. Nat Genet. 2022. PMID: 35864192 Free PMC article.
Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel AR, Szabo Q, Chiariello AM, Chudzik K, Schöpflin R, Rothe P, Mattei AL, Zehnder T, Harnett D, Laupert V, Bianco S, Hetzel S, Glaser J, Phan MHQ, Schindler M, Ibrahim DM, Paliou C, Esposito A, Prada-Medina CA, Haas SA, Giere P, Vingron M, Wittler L, Meissner A, Nicodemi M, Cavalli G, Bantignies F, Mundlos S, Robson MI. Ringel AR, et al. Among authors: hetzel s. Cell. 2022 Sep 29;185(20):3689-3704.e21. doi: 10.1016/j.cell.2022.09.006. Cell. 2022. PMID: 36179666 Free PMC article.
229 results